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Diosgenin and galactomannans, natural products in the pharmaceutical sciences
Clinical Phytoscience Pub Date : 2021-06-07 , DOI: 10.1186/s40816-021-00288-y
Mohamad Hesam Shahrajabian , Wenli Sun , Diorge Jonatas Marmitt , Qi Cheng

Diosgenin is an isospirostane derivative, which is a steroidal sapogenin and the product of acids or enzymes hydrolysis process of dioscin and protodioscin. Galactomannans are heteropolysaccharides composed of D-mannose and D-galactose, which are major sources of locust bean, guar, tara and fenugreek. Literature survey was accomplished using multiple databases including PubMed, Science Direct, ISI web of knowledge and Google Scholar. Four major sources of seed galactomannans are locust bean (Ceratonia siliqua), guar (Cyamopsis tetragonoloba), tara (Caesalpinia spinosa Kuntze), and fenugreek (T.foenum-graecum). Diosgenin has effect on immune system, lipid system, inflammatory and reproductive systems, caner, metabolic process, blood system, blood glucose and calcium regulation. The most important pharmacological benefits of galactomannan are antidiabetic, antioxidant, anticancer, anticholinesterase, antiviral activities, and appropriate for dengue virus and gastric diseases. Considering the importance of diosgenin and galactomannans, the obtained findings suggest potential of diosgenin and galactomannans as natural products in pharmaceutical industries.

中文翻译:

薯蓣皂苷元和半乳甘露聚糖,制药科学中的天然产物

薯蓣皂甙元是异螺甾烷衍生物,是甾体皂甙元,是薯蓣皂甙和原薯蓣皂甙的酸或酶水解过程的产物。半乳甘露聚糖是由 D-甘露糖和 D-半乳糖组成的杂多糖,是刺槐豆、瓜尔豆、塔拉和胡芦巴的主要来源。文献调查使用多个数据库完成,包括 PubMed、Science Direct、ISI web of Knowledge 和 Google Scholar。种子半乳甘露聚糖的四种主要来源是刺槐豆 (Ceratonia siliqua)、瓜尔豆 (Cyamopsis tetragonoloba)、塔拉 (Caesalpinia spinosa Kuntze) 和胡芦巴 (T.foenum-graecum)。薯蓣皂苷元对免疫系统、脂质系统、炎症和生殖系统、癌症、代谢过程、血液系统、血糖和钙调节有影响。半乳甘露聚糖最重要的药理作用是抗糖尿病、抗氧化、抗癌、抗胆碱酯酶、抗病毒活性,适用于登革热病毒和胃病。考虑到薯蓣皂甙元和半乳甘露聚糖的重要性,所获得的研究结果表明薯蓣皂甙元和半乳甘露聚糖作为天然产品在制药工业中的潜力。
更新日期:2021-06-07
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