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Homocysteine is potential serological marker for predicting the risk of deep venous thrombosis of the lower extremities in patients received operation of lower limb fracture
Pteridines ( IF 0.4 ) Pub Date : 2021-01-01 , DOI: 10.1515/pteridines-2020-0027
Xiao Chen 1 , Weiran Zhang 2 , Jingmin Huang 1
Affiliation  

Objective The aim of the study is to investigate the correlations among serum homocysteine (Hcy), D-dimer, and the risk of developing deep venous thrombosis (DVT) of the lower extremities in patients who underwent operation for lower limb fracture. Methods Seventy-five cases who underwent operation for lower limb fracture were included and further divided into DVT group ( n = 26) and control group ( n = 49) based on post-DVT diagnostic criteria. The serum Hcy and D-dimer were examined 48 h after operation. The serum Hcy and D-dimer levels were compared between the two groups. The correlation between serum Hcy and D-dimer was investigated by the Pearson correlation test. The receiver-operating characteristic (ROC) curve was applied to evaluate the diagnostic performance of serum Hcy and D-dimer as serological markers for DVT. Results The serum Hcy concentrations were 11.96 ± 3.98 μmol/L and 7.92 ± 3.27 μmol/L for DVT and control groups, respectively, with statistical difference ( t = 4.72, P < 0.01). The serum D-dimer in the DVT group was significantly higher than that of the control group (8.99 ± 4.50 vs 1.70 ± 2.11) μg/mL with statistical difference ( t = 9.56, P < 0.01). Line regression analysis indicated that serum Hcy was positively correlated with serum D-dimer concentration and can be demonstrated by the equation of Y = 0.6651* X + 1.036 for the DVT group. Using serum Hcy as the biomarker for predicting DVT, the prediction sensitivity and specificity were 76.92 and 71.44%, respectively, with the AUC of 0.7804 under the cut-point of 9.54 μmol/L. For serum D-dimer, the prediction sensitivity and specificity were 96.15 and 73.47%, respectively, with the area under the ROC (AUC) of 0.9455 under the cut-point of 1.66 μg/mL. Conclusion Serum Hcy was significantly elevated in DTV patients, and hence, it can be applied as a serological marker for DVT prediction in patients who underwent operation for lower limb fracture. However, the DVT prediction performance of serum Hcy was inferior to D-dimer especially for diagnostic sensitivity.

中文翻译:

同型半胱氨酸是预测下肢骨折手术患者下肢深静脉血栓形成风险的潜在血清学标志物

目的探讨下肢骨折手术患者血清同型半胱氨酸(Hcy)、D-二聚体与下肢深静脉血栓形成(DVT)风险的相关性。方法 将75例下肢骨折手术患者按DVT后诊断标准分为DVT组(n=26)和对照组(n=49)。术后48 h检测血清Hcy和D-二聚体。比较两组血清Hcy和D-二聚体水平。血清Hcy与D-二聚体的相关性采用Pearson相关检验。应用受试者工作特征(ROC)曲线来评估血清 Hcy 和 D-二聚体作为 DVT 血清学标志物的诊断性能。结果 DVT组和对照组血清Hcy浓度分别为11.96±3.98μmol/L和7.92±3.27μmol/L,差异有统计学意义(t=4.72,P<0.01)。DVT组血清D-二聚体显着高于对照组(8.99±4.50 vs 1.70±2.11)μg/mL,差异有统计学意义(t=9.56,P<0.01)。线性回归分析表明,血清 Hcy 与血清 D-二聚体浓度呈正相关,DVT 组可由方程 Y = 0.6651* X + 1.036 证明。以血清Hcy作为预测DVT的生物标志物,预测灵敏度和特异性分别为76.92%和71.44%,在9.54 μmol/L的临界点下AUC为0.7804。对于血清 D-二聚体,预测灵敏度和特异性分别为 96.15% 和 73.47%,ROC (AUC) 下面积在 1.66 μg/mL 的临界点下为 0.9455。结论 DTV患者血清Hcy显着升高,可作为下肢骨折手术患者DVT预测的血清学指标。然而,血清 Hcy 的 DVT 预测性能不如 D-二聚体,尤其是在诊断敏感性方面。
更新日期:2021-01-01
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