We determined the incidence and clinical manifestations of human brucellosis from patients who attended a referral hospital in South of Saudi Arabia. A record-based retrospective study was conducted from January 2015 to December 2019 at King Abdulla Hospital, Bisha, Saudi Arabia. Information on patients' demographic characteristics, detailed records of signs and symptoms, and the laboratory findings were reviewed. Of 6,586 patients included, 15.8% (n = 1,041) were infected with brucellosis. The age of infected individuals ranged from five to 95 years, with an average of 35.1 ± 21.2 years. Most infected patients were male (72.3%). Young adults (26-44 years) were the most common age group with the disease (34.1%). The annual rate of infection significantly decreased (P < 0.0001) from 33.2% in 2015 to 12.5% in 2019. An escalating number of brucellosis cases was seen in the spring and peaked during the summer. Fever (35.3%), joint pain (25.5%), generalized body ache (10.7%), and neurological symptoms (10.0%) were the most frequent clinical manifestation associated with brucellosis. Joint pain was commonly found among children (44.4%). Neurological findings were more frequent among adult patients. The study concluded that brucellosis is endemic in Southern Saudi Arabia and needs local health authority to implement preventive and educational program measures. Infected patients may present with diverse, nonspecific clinical manifestations that require intuition from clinicians to detect the disease.

中文翻译：

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2015-2019年沙特阿拉伯南部一家转诊医院人布鲁氏菌病发病率及临床表现。

我们确定了在沙特阿拉伯南部转诊医院就诊的患者的人类布鲁氏菌病发病率和临床表现。2015 年 1 月至 2019 年 12 月在沙特阿拉伯比沙的阿卜杜拉国王医院进行了一项基于记录的回顾性研究。审查了有关患者人口统计学特征、体征和症状的详细记录以及实验室检查结果的信息。在纳入的 6,586 名患者中，15.8% (n = 1,041) 感染了布鲁氏菌病。感染者的年龄从 5 岁到 95 岁不等，平均为 35.1 ± 21.2 岁。大多数感染患者为男性（72.3%）。年轻人（26-44 岁）是该病最常见的年龄组（34.1%）。年感染率从 2015 年的 33.2% 显着下降（P < 0.0001）至 2019 年的 12.5%。春季布鲁氏菌病病例数不断增加，夏季达到高峰。发热（35.3%）、关节痛（25.5%）、全身酸痛（10.7%）和神经系统症状（10.0%）是布鲁氏菌病最常见的临床表现。关节痛常见于儿童（44.4%）。成人患者的神经系统检查结果更为常见。该研究得出结论，布鲁氏菌病在沙特阿拉伯南部流行，需要当地卫生当局实施预防和教育计划措施。受感染的患者可能会出现多种非特异性临床表现，需要临床医生凭直觉来检测疾病。0%）是与布鲁氏菌病相关的最常见的临床表现。关节痛常见于儿童（44.4%）。成人患者的神经系统检查结果更为常见。该研究得出结论，布鲁氏菌病在沙特阿拉伯南部流行，需要当地卫生当局实施预防和教育计划措施。受感染的患者可能会出现多种非特异性临床表现，需要临床医生凭直觉来检测疾病。0%）是与布鲁氏菌病相关的最常见的临床表现。关节痛常见于儿童（44.4%）。成人患者的神经系统检查结果更为常见。该研究得出结论，布鲁氏菌病在沙特阿拉伯南部流行，需要当地卫生当局实施预防和教育计划措施。受感染的患者可能会出现多种非特异性临床表现，需要临床医生凭直觉来检测疾病。