Abstract

Different feeding patterns exhibit completely different and heritable growth properties in livestock, but the underlying epigenetic mechanisms remain unclear. Here, we investigated genome-wide DNA-methylation and gene expression under grazing and confinement regimen feeding strategies with Lvliang Black goat. We identified 102 differently expressed genes and 7,833 differentially methylated regions (DMRs) between the two groups. Integrating DNA-methylation and gene expression showed that genes in DMRs exhibit significantly different expression level (FDR < 0.05). KEGG pathway analysis indicated that most of the genes involved in environment adaptation pathways like lipid transpor and metabolism immunity. In sum, our data provided insight into the epigenetic mechanism underlying growth property difference resulting from distinct feeding patterns in goat, and also offered theoretical basis for the rational utilization of germplasm resources of local breeds.

Supplemental data for this article is available online at https://doi.org/10.1080/13102818.2021.1914164 .

摘要

不同的饲养模式在家畜中表现出完全不同的和可遗传的生长特性，但潜在的表观遗传机制仍不清楚。在这里，我们研究了吕梁黑山羊在放牧和禁闭喂养策略下的全基因组 DNA 甲基化和基因表达。我们在两组之间确定了 102 个不同表达的基因和 7,833 个差异甲基化区域 (DMR)。整合 DNA 甲基化和基因表达表明 DMR 中的基因表现出显着不同的表达水平（FDR < 0.05）。KEGG通路分析表明，大多数基因参与环境适应通路，如脂质转运和代谢免疫。总共，

本文的补充数据可在 https://doi.org/10.1080/13102818.2021.1914164 在线获得。