当前位置:
X-MOL 学术
›
Virus Evol.
›
论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Genomic epidemiology of SARS-CoV-2 transmission lineages in Ecuador
Virus Evolution ( IF 5.3 ) Pub Date : 2021-06-03 , DOI: 10.1093/ve/veab051 Bernardo Gutierrez 1 , Sully Márquez 2 , Belén Prado-Vivar 2 , Mónica Becerra-Wong 2 , Juan José Guadalupe 3 , Darlan Da Silva Candido 1 , Juan Carlos Fernandez-Cadena 4 , Gabriel Morey-Leon 5 , Rubén Armas-Gonzalez 6 , Derly Madeleiny Andrade-Molina 4 , Alfredo Bruno 7 , Domenica De Mora 7 , Maritza Olmedo 7 , Denisse Portugal 7 , Manuel Gonzalez 7 , Alberto Orlando 7 , Jan Felix Drexler 8 , Andres Moreira-Soto 8 , Anna-Lena Sander 8 , Sebastian Brünink 8 , Arne Kühne 8 , Leandro Patiño 7 , Andrés Carrazco-Montalvo 9 , Orson Mestanza 10 , Jeannete Zurita 11 , Gabriela Sevillano 12 , Louis Du Plessis 1 , John T McCrone 13 , Josefina Coloma 14 , Gabriel Trueba 2 , Verónica Barragán 2 , Patricio Rojas-Silva 2 , Michelle Grunauer 15 , Moritz U G Kraemer 1 , Nuno R Faria 1 , Marina Escalera-Zamudio 1 , Oliver G Pybus 1 , Paúl Cárdenas 2
Virus Evolution ( IF 5.3 ) Pub Date : 2021-06-03 , DOI: 10.1093/ve/veab051 Bernardo Gutierrez 1 , Sully Márquez 2 , Belén Prado-Vivar 2 , Mónica Becerra-Wong 2 , Juan José Guadalupe 3 , Darlan Da Silva Candido 1 , Juan Carlos Fernandez-Cadena 4 , Gabriel Morey-Leon 5 , Rubén Armas-Gonzalez 6 , Derly Madeleiny Andrade-Molina 4 , Alfredo Bruno 7 , Domenica De Mora 7 , Maritza Olmedo 7 , Denisse Portugal 7 , Manuel Gonzalez 7 , Alberto Orlando 7 , Jan Felix Drexler 8 , Andres Moreira-Soto 8 , Anna-Lena Sander 8 , Sebastian Brünink 8 , Arne Kühne 8 , Leandro Patiño 7 , Andrés Carrazco-Montalvo 9 , Orson Mestanza 10 , Jeannete Zurita 11 , Gabriela Sevillano 12 , Louis Du Plessis 1 , John T McCrone 13 , Josefina Coloma 14 , Gabriel Trueba 2 , Verónica Barragán 2 , Patricio Rojas-Silva 2 , Michelle Grunauer 15 , Moritz U G Kraemer 1 , Nuno R Faria 1 , Marina Escalera-Zamudio 1 , Oliver G Pybus 1 , Paúl Cárdenas 2
Affiliation
Characterisation of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) genetic diversity through space and time can reveal trends in virus importation and domestic circulation and permit the exploration of questions regarding the early transmission dynamics. Here, we present a detailed description of SARS-CoV-2 genomic epidemiology in Ecuador, one of the hardest hit countries during the early stages of the coronavirus-19 pandemic. We generated and analysed 160 whole genome sequences sampled from all provinces of Ecuador in 2020. Molecular clock and phylogeographic analysis of these sequences in the context of global SARS-CoV-2 diversity enable us to identify and characterise individual transmission lineages within Ecuador, explore their spatiotemporal distributions, and consider their introduction and domestic circulation. Our results reveal a pattern of multiple international importations across the country, with apparent differences between key provinces. Transmission lineages were mostly introduced before the implementation of non-pharmaceutical interventions, with differential degrees of persistence and national dissemination.
中文翻译:
厄瓜多尔 SARS-CoV-2 传播谱系的基因组流行病学
通过空间和时间表征严重急性呼吸系统综合症冠状病毒-2 (SARS-CoV-2) 遗传多样性可以揭示病毒输入和国内传播的趋势,并允许探索有关早期传播动力学的问题。在这里,我们详细描述了厄瓜多尔的 SARS-CoV-2 基因组流行病学,厄瓜多尔是冠状病毒 19 大流行早期受灾最严重的国家之一。我们生成并分析了 2020 年从厄瓜多尔所有省份采样的 160 个全基因组序列。在全球 SARS-CoV-2 多样性的背景下对这些序列进行分子钟和系统地理学分析,使我们能够识别和表征厄瓜多尔境内的个体传播谱系,探索它们时空分布,并考虑它们的引入和国内流通。我们的结果揭示了全国多个国际输入的模式,重点省份之间存在明显差异。传播谱系大多是在实施非药物干预措施之前引入的,具有不同程度的持久性和全国传播。
更新日期:2021-06-03
中文翻译:
厄瓜多尔 SARS-CoV-2 传播谱系的基因组流行病学
通过空间和时间表征严重急性呼吸系统综合症冠状病毒-2 (SARS-CoV-2) 遗传多样性可以揭示病毒输入和国内传播的趋势,并允许探索有关早期传播动力学的问题。在这里,我们详细描述了厄瓜多尔的 SARS-CoV-2 基因组流行病学,厄瓜多尔是冠状病毒 19 大流行早期受灾最严重的国家之一。我们生成并分析了 2020 年从厄瓜多尔所有省份采样的 160 个全基因组序列。在全球 SARS-CoV-2 多样性的背景下对这些序列进行分子钟和系统地理学分析,使我们能够识别和表征厄瓜多尔境内的个体传播谱系,探索它们时空分布,并考虑它们的引入和国内流通。我们的结果揭示了全国多个国际输入的模式,重点省份之间存在明显差异。传播谱系大多是在实施非药物干预措施之前引入的,具有不同程度的持久性和全国传播。