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Exercise training decreases intercostal and transversus abdominis muscle blood flows in heart failure rats during submaximal exercise
Respiratory Physiology & Neurobiology ( IF 2.3 ) Pub Date : 2021-06-04 , DOI: 10.1016/j.resp.2021.103710
Joshua R Smith 1 , Daniel M Hirai 2 , Steven W Copp 3 , Scott K Ferguson 4 , Clark T Holdsworth 5 , K Sue Hageman 6 , David C Poole 5 , Timothy I Musch 5
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Diaphragm muscle blood flow (BF) and vascular conductance (VC) are elevated with chronic heart failure (HF) during exercise. Exercise training (ExT) elicits beneficial respiratory muscle and pulmonary system adaptations in HF. We hypothesized that diaphragm BF and VC would be lower in HF rats following ExT than their sedentary counterparts (Sed). Respiratory muscle BFs and mean arterial pressure were measured via radiolabeled microspheres and carotid artery catheter, respectively, during submaximal treadmill exercise (20 m/min, 5 % grade). During exercise, no differences were present between HF + ExT and HF + Sed in diaphragm BFs (201 ± 36 vs. 227 ± 44 mL/min/100 g) or VCs (both, p > 0.05). HF + ExT compared to HF + Sed had lower intercostal BF (27 ± 3 vs. 41 ± 5 mL/min/100 g) and VC (0.21 ± 0.02 vs. 0.31 ± 0.04 mL/min/mmHg/100 g) during exercise (both, p < 0.05). Further, HF + ExT compared to HF + Sed had lower transversus abdominis BF (20 ± 1 vs. 35 ± 6 mL/min/100 g) and VC (0.14 ± 0.02 vs. 0.27 ± 0.05 mL/min/mmHg/100 g) during exercise (both, p < 0.05). These data suggest that exercise training lowers the intercostal and transversus abdominis BF responses in HF rats during submaximal treadmill exercise.



中文翻译:

运动训练可减少次极量运动期间心力衰竭大鼠的肋间和腹横肌血流量

运动过程中慢性心力衰竭 (HF) 导致膈肌血流量 (BF) 和血管电导 (VC) 升高。运动训练 (ExT) 在 HF 中引起有益的呼吸肌和肺系统适应。我们假设在 ExT 后 HF 大鼠的隔膜 BF 和 VC 会低于其久坐的对应物 (Sed)。在次最大跑步机运动(20 m/min,5% 等级)期间,分别通过放射性标记的微球和颈动脉导管测量呼吸肌 BF 和平均动脉压。在运动过程中,HF + ExT 和 HF + Sed 在隔膜 BF(201 ± 36 对 227 ± 44 mL/min/100 g)或 VC(两者,p > 0.05)中没有差异。与 HF + Sed 相比,HF + ExT 具有较低的肋间 BF(27 ± 3 vs. 41 ± 5 mL/min/100 g)和 VC(0.21 ± 0.02 vs. 0.31 ± 0。运动期间 04 mL/min/mmHg/100 g)(两者,p < 0.05)。此外,与 HF + Sed 相比,HF + ExT 的腹横肌 BF (20 ± 1 vs. 35 ± 6 mL/min/100 g) 和 VC (0.14 ± 0.02 vs. 0.27 ± 0.05 mL/min/mmHg/100 g) ) 运动期间(两者,p < 0.05)。这些数据表明,运动训练降低了 HF 大鼠在次最大跑步机运动期间的肋间和腹横肌 BF 反应。

更新日期:2021-06-10
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