Abstract

A phytochemical investigation of the stems and leaves of Piper wallichii led to the isolation of two new compounds, an aryl alkanone, piwalkanone (1) and a dioxoaporphine alkaloid, piwallidione (2), together with nine known compounds, a dioxoaporphine alkaloid, cepharadione A (3); two aristolactams, piperolactam A (4) and stigmalactam (5); a piperidine, piperine (6); four isobutylamides, piperlonguminine (7), pellitorine (8), N‐isobutyl‐2E,4E‐octadecadienamide (9), and guineensine (10); and a tyramine, N-trans-feruloyltyramine (11). Their structures were elucidated on the basis of spectroscopic evidence (IR, ¹H NMR, ¹³C NMR and 2 D NMR) and MS. Compounds 2 and 3 showed inhibitory activities against pathogenic bacteria, Bacillus cereus, Bacillus subtilis and Staphylococcus aureus.

摘要

对Piper wallichii茎和叶的植物化学研究导致分离出两种新化合物，一种芳基​​烷酮，piwalkanone ( 1 ) 和一种二氧杂卟啉生物碱，piwallidione ( 2 )，以及九种已知化合物，一种二氧杂卟啉生物碱，头孢二酮 A ( 3 )；两种马兜铃内酰胺，哌内酰胺 A ( 4 ) 和 stigmalactam ( 5 )；哌啶，胡椒碱（6）；四种异丁基酰胺，胡椒粉（7），pellitorine（8），N-异丁基-2E ，4E-十八碳二烯酰胺（9）和guineensine（10）；和酪胺，N-反式-阿魏酰酪胺( 11 )。基于光谱证据（IR、¹ H NMR、¹³ C NMR 和2 D NMR）和MS 阐明了它们的结构。化合物2和3对病原菌、蜡状芽孢杆菌、枯草芽孢杆菌和金黄色葡萄球菌具有抑制活性。