An efficient, time effective and greener procedure of C–C bond formation under mild condition has been developed for the production of ethyl (E) 2-cyano-3 substituted aryl/alkyl acrylate compounds. Different aryl/alkyl aldehydes on reaction with ethyl cyanoacetate/malanonitrile in the presence of sodium ethoxide (20 mol%) in ethanol at reflux temperature for 1 h as well as at room temperature (25 °C) for 2–8 h yielded the desired products. A carbon nucleophile is added to a carbonyl function of aldehyde followed by a dehydration yielding the corresponding ethyl (E) 2-cyano-3 substituted aryl/alkyl acrylate compounds in fairly good yields.

Graphical abstract

中文翻译：

---

用于生产乙基 (E)-2-氰基-3-取代的芳基/烷基丙烯酸酯的简便的乙醇钠介导的 Knoevenagel 缩合反应

已开发出一种在温和条件下形成 C-C 键的高效、省时且更环保的程序，用于生产 ( E ) 2-氰基-3 取代的芳基/丙烯酸烷基酯化合物。不同的芳基/烷基醛与氰基乙酸乙酯/丙二腈在乙醇钠（20 mol%）存在下在乙醇中回流 1 小时以及在室温 (25 °C) 下反应 2-8 小时，得到所需的产品。将碳亲核试剂加到醛的羰基官能团上，然后脱水以相当好的收率得到相应的 ( E ) 2-氰基-3 取代的芳基/烷基丙烯酸酯化合物。

图形概要