In order to assess the health risk of low-dose radiation to radiation professionals, monitoring is performed through chromosomal aberration analysis and micronuclei (MN) analysis. MN formation has drawbacks for monitoring in the low-dose range. Nucleoplasmic bridge (NPB) analysis, with a lower background level, has good dose-response relationships at both high and relatively low dose ranges. Dicentric and ring chromosomes were analyzed in 199 medical radiation professionals, and NPB/MN yields were analyzed in 205 radiation professionals. The effects of sex, age of donor, types of work, and length of service on these cytogenetic endpoints were also analyzed. The yields of the three cytogenetic endpoints were significantly higher in radiation professionals versus controls. Frequencies of dicentric plus ring chromosomes were affected by length of service. NPB frequencies were influenced by type of work and length of service. MN yields were affected not only by types of work and length of service but also by donor sex and age. In conclusion, dicentric plus ring chromosomes, NPB, and MN can be induced by low-dose radiation in radiation professionals. NPB is a potential biomarker to assess the health risk of occupational low-dose radiation exposure.

为了评估低剂量辐射对放射专业人员的健康风险，通过染色体畸变分析和微核 (MN) 分析进行监测。MN 的形成对于在低剂量范围内进行监测存在缺陷。核质桥 (NPB) 分析具有较低的背景水平，在高剂量和相对低剂量范围内都具有良好的剂量反应关系。对 199 名医疗放射专业人员进行了双着丝粒染色体和环状染色体分析，并对 205 名放射专业人员进行了 NPB/MN 产率分析。还分析了性别、捐赠者年龄、工作类型和服务时间对这些细胞遗传学终点的影响。与对照组相比，放射专业人员的三个细胞遗传学终点的产量明显更高。双着丝粒加环染色体的频率受服务时间的影响。NPB 频率受工作类型和服务年限的影响。MN 产量不仅受工作类型和服务年限的影响，还受捐助者性别和年龄的影响。总之，放射专业人员的低剂量放射可诱发双着丝粒加环染色体、NPB 和 MN。NPB 是评估职业低剂量辐射暴露健康风险的潜在生物标志物。