The specific status of active substance candidates for substitution (CfS) is detailed by Article 24 of plant protection Commission Regulation EC No 1107/2009 (PPP Regulation). The criteria of candidates for substitution are now clearly defined: low acceptable daily intake/acute reference dose/acceptable operator exposure level or two persistent, bio-accumulative or toxic criteria, or by nature of the critical effects: non-active isomers, carcinogen 1A/1B, toxic for reproduction 1A/1B or endocrine disruption properties, with these later properties now being well characterised. The total number of active substances CfS has been in constant evolution since 2011, with the first batch of candidates for substitution being published in 2015 and updated since then. After a slow decrease, growth is again observed, with another list of active substances being granted this status. CfS are substances targeted by the PPP Regulation that are supposed to be cancelled or non-renewed at the active substance level or substituted at the market authorisation level. CfS are also supposed to be replaced by substances with better toxicological profiles. However, after five years of implementation of the status, their number, which is intended to decrease, remains high, at sixty residual CfS. We exhibit here their evolution.

植物保护委员会法规 EC No 1107/2009（PPP 法规）第 2​​4 条详细说明了替代活性物质候选物 (CfS) 的具体状态。现在明确定义了替代候选者的标准：低可接受的每日摄入量/急性参考剂量/可接受的操作员暴露水平或两个持久性、生物累积性或毒性标准，或关键影响的性质：非活性异构体、致癌物 1A /1B，对生殖有毒 1A/1B 或内分泌干扰特性，这些后来的特性现在已得到很好的表征。自 2011 年以来，活性物质 CfS 的总数一直在不断发展，第一批替代候选物于 2015 年发布并自那时起更新。在缓慢下降之后，再次观察到增长，另一份活性物质清单被授予此地位。CfS 是 PPP 法规的目标物质，应该在活性物质水平上被取消或不再更新，或者在市场授权水平上被替代。CfS 也应该被具有更好毒理学特征的物质所取代。然而，在该地位实施五年后，其数量（本应减少）仍然很高，剩余 CfS 为 60 个。我们在这里展示他们的演变。他们的数量本来打算减少，但仍然很高，有 60 个剩余 CfS。我们在这里展示他们的演变。他们的数量本来打算减少，但仍然很高，有 60 个剩余 CfS。我们在这里展示他们的演变。