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Rare cases of rare diseases: Re-examining early 20th century cases of anencephaly from the collection of the Moscow State University, Russia
International Journal of Paleopathology ( IF 1.2 ) Pub Date : 2021-06-04 , DOI: 10.1016/j.ijpp.2021.05.008
N Berezina 1 , A Buzhilova 1
Affiliation  

Objective

Documented cases of anencephaly were used to increase differential criteria of this rare disease.

Material

Two skulls from a 20th-century documented medical collection at the Moscow State University diagnosed with anencephaly.

Methods

The skulls were evaluated based on macroscopic qualitative and quantitative morphological signs and X-ray analyses.

Results

Metric values and morphological features differ between the two cases of anencephaly noted in the collection and the published data based on normal fetal and neonatal remains.

Conclusions

Analyses of medical collections helps to increase the number of diagnostic criteria for recognition and diagnosis of anencephaly in archaeological skeletons.

Significance

Improvement in the recognition of skeletal alterations associated with anencephaly is key towards improving our understanding of rare diseases in the past.

Limitations

The fragility of skeletal elements of fetal and neonate individuals can complicate thorough analyses.

Suggestions for further research

Continue to identify cases of anencephaly cases in medical collections and in archaeological contexts.



中文翻译:

罕见病的罕见病例:重新审视俄罗斯莫斯科国立大学收藏的 20 世纪早期无脑畸形病例

客观的

记录在案的无脑畸形病例被用来增加这种罕见疾病的鉴别标准。

材料

从20两个头骨-century在莫斯科国立大学记录集医疗诊断患有无脑畸形。

方法

根据宏观定性和定量形态学迹象和 X 射线分析对头骨进行评估。

结果

收集到的两例无脑畸形病例与基于正常胎儿和新生儿遗骸的已发表数据的度量值和形态特征不同。

结论

对医学藏品的分析有助于增加用于识别和诊断考古骨骼中无脑畸形的诊断标准的数量。

意义

提高对与无脑畸形相关的骨骼改变的认识是提高我们过去对罕见疾病理解的关键。

限制

胎儿和新生儿骨骼元素的脆弱性会使彻底的分析复杂化。

进一步研究的建议

继续在医学收藏和考古环境中识别无脑畸形病例。

更新日期:2021-06-05
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