当前位置: X-MOL 学术Eur. J. Org. Chem. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Nickel-Catalyzed Asymmetric Hydrogenation of Hydrazones
European Journal of Organic Chemistry ( IF 2.8 ) Pub Date : 2021-06-04 , DOI: 10.1002/ejoc.202100642
Bowen Li 1 , Dan Liu 1 , Yanhua Hu 1 , Jianzhong Chen 1 , Zhenfeng Zhang 2 , Wanbin Zhang 1, 2, 3
Affiliation  

An asymmetric hydrogenation of hydrazones with a unique nickel catalyst has been developed for the synthesis of chiral hydrazines with up to 99 % yield and 99.4 : 0.6 er and a broad substrate scope. Deuterium labelling experiments indicated that the hydrazone substrates undergo imine-enamine tautomerization in the mixed solvents.
image


中文翻译:

腙的镍催化不对称氢化

使用独特的镍催化剂对腙进行不对称加氢已开发出用于合成手性肼的方法,收率高达 99%,er 为 99.4:0.6,且底物范围广泛。氘标记实验表明腙底物在混合溶剂中发生亚胺-烯胺互变异构化。
图像
更新日期:2021-06-18
down
wechat
bug