In a recent publication, Nayar et al. uncover specific inflammatory cell populations associated with Crohn’s disease (CD) pathogenesis, and a gp130-STAT3 signaling axis linked to disease in anti-TNF antibody treatment-refractory patients. Therefore, gp130 blockade might represent a potential CD therapy approach, perhaps in conjunction with existing anti-TNF treatment regimes.

中文翻译：

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阻断 gp130 以消除克罗恩病

在最近的出版物中，Nayar等人。揭示与克罗恩病 (CD) 发病机制相关的特定炎症细胞群，以及与抗 TNF 抗体治疗难治性患者的疾病相关的 gp130-STAT3 信号轴。因此，gp130 阻断可能代表一种潜在的 CD 治疗方法，可能与现有的抗 TNF 治疗方案相结合。