Severe acute respiratory syndrome coronavirus 2 has rapidly spread worldwide and resulted in the coronavirus disease 2019 (COVID-19) pandemic. The disease raised an unprecedented demand for intensive care support due to severe pulmonary dysfunction and multiorgan failure. Although the pulmonary system is the potential target of the COVID-19, recent reports have demonstrated that COVID-19 profoundly influences the cardiovascular system and the kidneys. Research studies on cadavers have shown that direct heart and kidney injury can be frequently seen in patients deceased due to COVID-19 infection. On the other hand, functional or structural dysfunction of the heart may deteriorate the renal function and vice versa. This concept is already known as the cardiorenal syndrome and may play a role in COVID-19. Proactive monitoring of micro- and macrohemodynamics could allow prompt correction of circulatory dysfunction and can be of pivotal importance in the prevention of acute kidney injury. Moreover, type and amount of fluid therapy and vasoactive drug support could help manage these patients either with or without mechanical ventilator support. This brief review outlines the current evidence regarding the COVID-19-related renal and cardiorenal complications and discusses potential hemodynamic management strategies.
Cardiorenal Med

中文翻译：

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严重 COVID-19 的心肺肾后果

严重急性呼吸系统综合症冠状病毒 2 已在全球迅速传播，并导致 2019 年冠状病毒病 (COVID-19) 大流行。由于严重的肺功能障碍和多器官衰竭，这种疾病对重症监护支持提出了前所未有的需求。尽管肺系统是 COVID-19 的潜在目标，但最近的报告表明，COVID-19 对心血管系统和肾脏产生了深远的影响。对尸体的研究表明，在因 COVID-19 感染而死亡的患者中经常可以看到直接的心脏和肾脏损伤。另一方面，心脏的功能或结构功能障碍可能会使肾功能恶化，反之亦然。这个概念已经被称为心肾综合征，可能在 COVID-19 中发挥作用。积极监测微观和宏观血流动力学可以迅速纠正循环功能障碍，并且在预防急性肾损伤方面具有关键意义。此外，液体疗法和血管活性药物支持的类型和数量可以帮助管理这些患者，无论是否有机械呼吸机支持。这篇简短的综述概述了关于 COVID-19 相关肾脏和心肾并发症的当前证据，并讨论了潜在的血流动力学管理策略。
心肾医学