Inland fish is one of the main protein sources of the regular diets of remote communities in Sri Lanka where the incidences of chronic kidney disease of unknown etiology (CKDu) have significantly increased. Nevertheless, the nephrotoxic heavy metals accumulated in the reservoir sediments may affect the bio-community, especially in fish through the food chains. To study the problem, concentrations of heavy metals (Cd, Pb, As, Cr, Cu, Zn, and Mn) in two common edible wild and commercial inland fish species and associated reservoir sediments were investigated in selected CKDu endemic and non-endemic areas in Sri Lanka. The concentrations of heavy metals were 1000 times higher in sediments than in dorsal fish muscles. Based on SQGs, Sediment-bound As, Cu, Zn, and Cd contents which exceeded the Effect range-low and median levels, implicated the harmful biological impacts to the living organisms inhabiting the Ulhitiya reservoir in the CKDu hotspot, including fish. Significant strong correlations in Cd, Pb, and Zn between the reservoir sediments and dorsal muscles of E. suratensis and O. niloticus confirmed that presume. Calculated Hazard Indices (HIs) were higher in E. suratensis (wild species) than O. niloticus (commercial species) irrespective of the location, and nephrotoxic heavy metals, including Pb, Cd, and As in fish muscles, contributed about 80% to the HI. Whether the estimated Target hazard quotients (THQs) for fish consumption were very much less than the threshold of 1, a relative possibility to the occurrence of chronic kidney failure of CKDu can exist due to exposure to the nephrotoxic heavy metals such as Pb, Cd, and As via fish consumption in the selected CKDu prevalence area. While a pollution event into an inland reservoir is often transitory, the pollutants’ effects may be long-lived due to their tendency to be absorbed in the sediments and then released into the food chain. Even though detected heavy metal contents have complied with acceptable limits for human consumption, long-term consumption as the main animal protein source can directly impact the prevalence of CKDu among the residents in Girandurukotte GND, Badulla, Sri Lanka.

内陆鱼类是斯里兰卡偏远社区常规饮食的主要蛋白质来源之一，那里不明原因慢性肾脏病（CKDu）的发病率显着增加。然而，蓄积在水库沉积物中的肾毒性重金属可能会影响生物群落，尤其是通过食物链影响鱼类。为了研究这个问题，在选定的 CKDu 流行区和非流行区调查了两种常见的可食用野生和商业内陆鱼类以及相关水库沉积物中重金属（Cd、Pb、As、Cr、Cu、Zn 和 Mn）的浓度在斯里兰卡。沉积物中重金属的浓度是鱼背肌肉的 1000 倍。基于 SQG、沉积物结合的 As、Cu、Zn 和 Cd 含量超过了影响范围 - 低和中值水平，暗示对居住在 CKDu 热点 Ulhitiya 水库中的生物（包括鱼类）的有害生物影响。水库沉积物与背肌之间 Cd、Pb 和 Zn 的显着强相关性E. suratensis和O. niloticus证实了这一假设。E. suratensis（野生物种）的计算危害指数 (HIs) 高于O. niloticus（商业物种）与位置无关，鱼类肌肉中的肾毒性重金属，包括 Pb、Cd 和 As，对 HI 的贡献约为 80%。无论鱼类消费的估计目标危害商数（THQs）是否远小于阈值1，由于暴露于具有肾毒性的重金属如Pb、Cd、和通过选定 CKDu 流行区的鱼类消费。虽然进入内陆水库的污染事件通常是短暂的，但污染物的影响可能会长期存在，因为它们倾向于被沉积物吸收，然后释放到食物链中。即使检测到的重金属含量符合人类消费的可接受限度，