当前位置: X-MOL 学术J. Int. Neuropsychol. Soc. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Impaired Behavioral Pattern Separation in Refractory Temporal Lobe Epilepsy and Mild Cognitive Impairment
Journal of the International Neuropsychological Society ( IF 2.6 ) Pub Date : 2021-06-03 , DOI: 10.1017/s1355617721000734
Sanam J Lalani 1 , Anny Reyes 2, 3, 4 , Erik Kaestner 3, 4 , Shauna M Stark 5 , Craig E L Stark 5 , David Lee 6 , Leena Kansal 6 , Jerry J Shih 6 , Christine N Smith 4, 7, 8 , Brianna M Paul 1 , Carrie R McDonald 2, 3, 4
Affiliation  

Objective:

Episodic memory impairment and hippocampal pathology are hallmark features of both temporal lobe epilepsy (TLE) and amnestic mild cognitive impairment (aMCI). Pattern separation (PS), which enables the distinction between similar but unique experiences, is thought to contribute to successful encoding and retrieval of episodic memories. Impaired PS has been proposed as a potential mechanism underling episodic memory impairment in aMCI, but this association is less established in TLE. In this study, we examined behavioral PS in patients with TLE and explored whether profiles of performance in TLE are similar to aMCI.

Method:

Patients with TLE, aMCI, and age-matched, healthy controls (HCs) completed a modified recognition task that relies on PS for the discrimination of highly similar lure items, the Mnemonic Similarity Task (MST). Group differences were evaluated and relationships between clinical characteristics, California Verbal Learning Test—Second Edition scores, and MST performance were tested in the TLE group.

Results:

Patients with TLE and aMCI demonstrated poorer PS performance relative to the HCs, but performance did not differ between the two patient groups. Neither the side of seizure focus nor having hippocampal sclerosis affected performance in TLE. However, TLE patients with clinically defined memory impairment showed the poorest performance.

Conclusion:

Memory performance on a task that relies on PS was disrupted to a similar extent in TLE and aMCI. The MST could provide a clinically useful tool for measuring hippocampus-dependent memory impairments in TLE and other neurological disorders associated with hippocampal damage.



中文翻译:

难治性颞叶癫痫和轻度认知障碍的行为模式分离受损

客观的:

情景记忆障碍和海马病理学是颞叶癫痫(TLE)和遗忘性轻度认知障碍(aMCI)的标志特征。模式分离(PS)可以区分相似但独特的经历,被认为有助于成功编码和检索情景记忆。PS 受损被认为是 aMCI 情景记忆受损的潜在机制,但这种关联在 TLE 中尚未建立。在这项研究中,我们检查了 TLE 患者的行为 PS,并探讨了 TLE 的表现概况是否与 aMCI 相似。

方法:

TLE、aMCI 患者和年龄匹配的健康对照 (HC) 完成了一项修改后的识别任务,该任务依赖于 PS 来区分高度相似的诱饵项目,即助记符相似性任务 (MST)。在 TLE 组中评估了组间差异,并测试了临床特征、加州语言学习测试第二版分数和 MST 表现之间的关系。

结果:

与 HC 相比,TLE 和 aMCI 患者的 PS 表现较差,但两个患者组之间的表现没有差异。癫痫病灶一侧或海马硬化均不会影响 TLE 的表现。然而,临床上明确的记忆障碍的 TLE 患者表现最差。

结论:

在 TLE 和 aMCI 中,依赖 PS 的任务的内存性能受到了类似程度的破坏。MST 可以提供临床上有用的工具,用于测量 TLE 中的海马依赖性记忆障碍以及与海马损伤相关的其他神经系统疾病。

更新日期:2021-06-03
down
wechat
bug