In this paper, we review our work in the last 10 years wherein we examined the sulfides in the acetone extracts of garlic (Allium sativum), onion (A. cepa), and Welsh onion (A. fistulosum), obtained and characterized the structures of new sulfides, three 3,4-dimethylthiolane-type sulfides from onion and Welsh onion, respectively, and four acyclic-type, nine 3,4-dimethyl- thiolane-type, four 2-methylthiolane (and thiane)-type, two 1,2-dithiolane-type, and two 2-oxothiolane-type sulfides, together with (E)-ajoene and one kujounin-type sulfide from garlic. During this process, structural corrections were made in onionin A group, garlicnin A, and garlicnin B group in some 3,4-dimethylthiolane-type sulfides. Next, hypothetical pathways for the production of the aforementioned sulfides were proposed. Furthermore, it was revealed that a typical 3,4-dimethylthiolane-type sulfide, onionin A₁ obtained from onion, having the isomeric structure of garlicnin B₁ obtained from garlic, decreased tumor proliferation and controlled tumor metastasis. These results showed that onionin A₁ is an effective agent for controlling tumors, and that the antitumor effects observed in vivo are likely caused by reversing the antitumor immune system. Activation of the antitumor immune system by onionin A₁ might be an effective adjuvant therapy for patients with osteosarcoma, ovarian cancer and other malignant tumors.

在本文中，我们回顾了我们过去 10 年的工作，其中我们检测了大蒜 ( Allium sativum )、洋葱 ( A. cepa ) 和威尔士洋葱 ( A. fistulosum ) 丙酮提取物中的硫化物，获得并表征了结构新的硫化物，分别来自洋葱和威尔士洋葱的三种 3,4-二甲基硫杂环戊烷型硫化物，以及四种无环型、九种 3,4-二甲基硫杂环戊烷型、四种 2-甲基硫杂环戊烷（和噻烷）型、两种1,2-二硫杂环戊烷型和两个 2-氧代硫杂环戊烷型硫化物，以及（E)-ajoene 和一种来自大蒜的 kujounin 型硫化物。在此过程中，对洋葱素 A 组、大蒜素 A 和大蒜素 B 组的一些 3,4-二甲基硫杂环戊烷型硫化物进行了结构校正。接下来，提出了生产上述硫化物的假设途径。此外，还揭示了典型的3,4-二甲基硫杂环硫烷型硫化物，从洋葱中获得的洋葱素A _{1具有从大蒜中获得的大蒜素B 1}的异构结构，可降低肿瘤增殖并控制肿瘤转移。这些结果表明，洋葱素 A ₁是控制肿瘤的有效药物，体内观察到的抗肿瘤作用很可能是由于抗肿瘤免疫系统的逆转引起的。_{洋葱素A 1}激活抗肿瘤免疫系统可能是骨肉瘤、卵巢癌和其他恶性肿瘤患者的有效辅助治疗。