Abstract

The effect of the structure of a mucoadhesive, insulin-containing, polymeric hydrogel on the rate of hormone release was studied. It has been shown that a decrease in the pore size of the hydrogel leads to an increase in the rate of insulin release, which contributes to a reduction in the time to achieve a positive effect upon oral administration of the drug while maintaining the physiological pathway of hormone penetration of the blood through the liver.

中文翻译：

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改性水凝胶作为口服胰岛素的载体

摘要

研究了粘膜粘附性、含胰岛素的聚合物水凝胶的结构对激素释放速率的影响。已经表明，水凝胶孔径的减小会导致胰岛素释放速率的增加，这有助于减少口服给药后达到积极作用的时间，同时维持胰岛素的生理途径。激素通过肝脏渗透血液。