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An antiviral trap made of protein nanofibrils and iron oxyhydroxide nanoparticles
Nature Nanotechnology ( IF 38.3 ) Pub Date : 2021-06-03 , DOI: 10.1038/s41565-021-00920-5
Archana Palika 1 , Antonius Armanious 1 , Akram Rahimi 1, 2 , Chiara Medaglia 3 , Matteo Gasbarri 4 , Stephan Handschin 1 , Antonella Rossi 5, 6 , Marie O Pohl 7 , Idoia Busnadiego 7 , Christian Gübeli 1 , Ravi B Anjanappa 8 , Sreenath Bolisetty 1, 2 , Mohammad Peydayesh 1 , Silke Stertz 7 , Benjamin G Hale 7 , Caroline Tapparel 3 , Francesco Stellacci 4, 9 , Raffaele Mezzenga 1, 6
Affiliation  

Minimizing the spread of viruses in the environment is the first defence line when fighting outbreaks and pandemics, but the current COVID-19 pandemic demonstrates how difficult this is on a global scale, particularly in a sustainable and environmentally friendly way. Here we introduce and develop a sustainable and biodegradable antiviral filtration membrane composed of amyloid nanofibrils made from food-grade milk proteins and iron oxyhydroxide nanoparticles synthesized in situ from iron salts by simple pH tuning. Thus, all the membrane components are made of environmentally friendly, non-toxic and widely available materials. The membrane has outstanding efficacy against a broad range of viruses, which include enveloped, non-enveloped, airborne and waterborne viruses, such as SARS-CoV-2, H1N1 (the influenza A virus strain responsible for the swine flu pandemic in 2009) and enterovirus 71 (a non-enveloped virus resistant to harsh conditions, such as highly acidic pH), which highlights a possible role in fighting the current and future viral outbreaks and pandemics.



中文翻译:

由蛋白质纳米纤维和氢氧化铁纳米颗粒制成的抗病毒陷阱

最大限度地减少病毒在环境中的传播是抗击疫情和流行病的第一道防线,但当前的 COVID-19 大流行表明,这在全球范围内是多么困难,尤其是以可持续和环保的方式。在这里,我们介绍并开发了一种可持续且可生物降解的抗病毒过滤膜,其由食品级牛奶蛋白制成的淀粉样蛋白纳米原纤维和通过简单的 pH 调节从铁盐原位合成的羟基氧化铁纳米颗粒组成。因此,所有膜组件均采用环保、无毒且广泛可用的材料制成。该膜对多种病毒具有出色的功效,包括包膜病毒、非包膜病毒、空气传播和水传播病毒,例如 SARS-CoV-2、

更新日期:2021-06-03
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