L1CAM is a transmembrane protein expressed on neurons that was presumed to be found on neuron-derived extracellular vesicles (NDEVs) in human biofluids. We developed a panel of single-molecule array assays to evaluate the use of L1CAM for NDEV isolation. We demonstrate that L1CAM is not associated with extracellular vesicles in human plasma or cerebrospinal fluid and therefore recommend against its use as a marker in NDEV isolation protocols.

中文翻译：

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L1CAM 与人脑脊液或血浆中的细胞外囊泡无关

L1CAM 是一种在神经元上表达的跨膜蛋白，推测存在于人类生物体液中神经元衍生的细胞外囊泡 (NDEV) 上。我们开发了一组单分子阵列检测来评估 L1CAM 在 NDEV 分离中的用途。我们证明 L1CAM 与人血浆或脑脊液中的细胞外囊泡无关，因此建议不要将其用作 NDEV 分离方案中的标记物。