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Multimodal polymer encapsulated CdSe/Fe3O4 nanoplatform with improved biocompatibility for two-photon and temperature stimulated bioapplications
Biomaterials Advances ( IF 7.9 ) Pub Date : 2021-06-02 , DOI: 10.1016/j.msec.2021.112224
Magda A Antoniak 1 , Robert Pązik 2 , Urszula Bazylińska 3 , Kamil Wiwatowski 4 , Anna Tomaszewska 2 , Magdalena Kulpa-Greszta 5 , Jagoda Adamczyk-Grochala 2 , Maciej Wnuk 2 , Sebastian Maćkowski 4 , Anna Lewińska 2 , Marcin Nyk 1
Affiliation  

Multimodal polymer encapsulated CdSe/Fe3O4 nanoplatforms with dual optical and magnetic properties have been fabricated. We demonstrate that CdSe/Fe3O4 nanocapsules (NCs) upon excitation with UV radiation or NIR fs-laser excitation exhibit intense one- or two-photon emission at 535 nm, whereas the combination of an alternating magnetic field and 808 nm IR laser excitation results in heat generation. Since anticancer therapies require relatively high doses of Fe3O4 nanoparticles (NPs) to induce biologically relevant temperature jumps, the therapeutic effects of 0.1 and 1 mg/mL Fe3O4 NCs and CdSe/Fe3O4 NCs were investigated using breast cancer cell lines, ER-positive MCF-7, and triple-negative MDA-MB-231 cells. Improved biocompatibility of CdSe/Fe3O4 NCs compared to Fe3O4 NCs was revealed at higher NCs concentration suggesting safe potential medical applications of CdSe/Fe3O4 NCs. In contrast, 1 mg/mL Fe3O4 NCs were found to be more cytotoxic to MDA-MB-231 than MCF-7 cells through iron-induced oxidative stress, lipid peroxidation, and concomitant ferroptotic cell death. We believe that Fe3O4 NCs-mediated cellular response may be heterogeneous that reflects, at least in part, cancer cell genotype, molecular phenotype, and pathological classification.



中文翻译:

多峰聚合物封装的 CdSe/Fe 3 O 4纳米平台,具有改善的双光子和温度刺激生物应用的生物相容性

已制造出具有双重光学和磁性特性的多峰聚合物封装的 CdSe/Fe 3 O 4纳米平台。我们证明了 CdSe/Fe 3 O 4纳米胶囊 (NCs) 在用紫外线辐射或 NIR fs 激光激发时表现出强烈的 535 nm 单光子或双光子发射,而交变磁场和 808 nm 红外激光的组合激发导致发热。由于抗癌治疗需要相对高剂量的 Fe 3 O 4纳米粒子 (NPs) 来诱导生物学相关的温度跳跃,因此 0.1 和 1 mg/mL Fe 3 O 4 NCs 和 CdSe/Fe 3 O的治疗效果使用乳腺癌细胞系、ER 阳性 MCF-7 和三阴性 MDA-MB-231 细胞研究了4 个NC。的CdSe /铁的改进的生物相容性3吨ö 4的NC相比的Fe 3 ö 4吨的NC被揭露在较高浓度的NC提示的CdSe /铁的安全潜在医疗应用3 ö 4的NC。相比之下,通过铁诱导的氧化应激、脂质过氧化和伴随的铁死亡细胞死亡,发现1 mg/mL Fe 3 O 4 NCs 对 MDA-MB-231 的细胞毒性比 MCF-7 细胞更强。我们认为 Fe 3 O 4 NCs 介导的细胞反应可能是异质的,至少部分反映了癌细胞基因型、分子表型和病理分类。

更新日期:2021-06-11
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