Introduction: Obesity, which can result from disease, genetics, nutrition, lifestyle, and insufficient physical activity, substantially increases an individual’s risk of complications and comorbidities. Exercise can be an effective strategy for achieving an energy balance and physiological fitness as part of obesity management. Additionally, probiotics, which are isolated from food and the environment, are being rapidly developed and have functional benefits for mitigating various metabolic dysfunctions associated with obesity. The potentially positive physiological and functional effects of exercise, probiotics, and exercise combined with probiotics should be elucidated in a model of diet-induced obesity. Methods: Bifidobacterium longum subsp. longum OLP-01 (OLP-01) was isolated from an elite Olympic-level athlete who exhibited physiological adaptations to peripheral fatigue caused by exercise training. In this current study, ICR strain mice were fed a high-fat diet (HFD) for 4 weeks to replicate an obesity model. The mice were divided into 5 groups according to the diet administered: control with normal diet, only HFD, HFD + exercise, HFD + OLP, and HFD + exercise + OLP groups. They were administered the probiotic and/or treadmill exercise training for 5 weeks, and their growth curve, physical activity, physiological adaptation, biochemical parameters, body composition, and glucose tolerance were assessed. Results: Compared with only exercise or only probiotics, a combination of probiotics and exercise significantly improved the weight, glucose tolerance, fat composition, and exercise-related oxidative stress of mice. Regular and programmed exercise with sufficient rest may be crucial to obesity improvement, and a combination of probiotics and exercise may synergistically assist obesity management and health promotion. Conclusion: OLP-01 probiotics combined with exercise training can be employed as a strategy for treating obesity. However, the exact regulatory mechanisms underlying this effect, possibly involving microbiota and associated metabolites, warrant further investigation.
Obes Facts

中文翻译：

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跑步机有氧运动联合长双歧杆菌OLP-01补充剂治疗高脂饮食诱导的肥胖小鼠模型

简介：肥胖可能由疾病、遗传、营养、生活方式和体力活动不足引起，大大增加了个体出现并发症和合并症的风险。作为肥胖管理的一部分，锻炼可以成为实现能量平衡和生理健康的有效策略。此外，从食物和环境中分离出来的益生菌正在迅速发展，并具有减轻与肥胖相关的各种代谢功能障碍的功能益处。应该在饮食诱导的肥胖模型中阐明运动、益生菌和运动与益生菌相结合的潜在积极的生理和功能影响。方法： 长双歧杆菌亚种。长OLP-01 (OLP-01) 是从一名奥林匹克级别的精英运动员身上分离出来的，该运动员对运动训练引起的外周疲劳表现出生理适应。在目前的这项研究中，ICR 品系小鼠被喂食高脂肪饮食 (HFD) 4 周以复制肥胖模型。根据给予的饮食将小鼠分为5组：正常饮食对照组、仅HFD组、HFD+运动组、HFD+OLP组和HFD+运动+OLP组。他们接受了 5 周的益生菌和/或跑步机运动训练，并评估了他们的生长曲线、体力活动、生理适应、生化参数、身体成分和葡萄糖耐量。结果：与仅运动或仅益生菌相比，益生菌和运动的组合显着改善了小鼠的体重、葡萄糖耐量、脂肪成分和运动相关的氧化应激。有规律和有计划的锻炼以及充足的休息可能对改善肥胖至关重要，益生菌和锻炼的结合可能会协同帮助肥胖管理和促进健康。结论： OLP-01益生菌结合运动训练可作为治疗肥胖的策略。然而，这种效应背后的确切调控机制，可能涉及微生物群和相关代谢物，值得进一步研究。
肥胖事实