An efficient and environmentally friendly synthetic methodology is preferred over conventional methods that require expensive chemicals & oxidants to achieve value-added organic transformations. Electrochemical conversions encounter conventional shortcomings and introduce easy scale-up methods to synthesize complex and hindered molecules employing electricity as a clean reagent and catalyzing entity. Electrochemical conditions minimize waste formation and increase the chances of getting the maximum amount of target products under ambient conditions. The Kolbe and related non-Kolbe electrolysis process where the anodic oxidation of carboxylic acids leads to decarboxylation can be used intelligently to form new bonds and achieve value-added molecules and stereoselective products. The memory of chirality, where we have contributed to, is a more fascinating strategy to achieve highly desired asymmetric products via electrochemical decarboxylation (ED). Besides this, coupling (homo, hetero), dimerization, addition, cyclization, and CH activation via ED are also significant aspects of this strategy. Flow electrochemistry and photochemistry using the ED strategy could enhance the selectivity and product yield, avoiding overoxidation. Herein, we discussed several examples of ED and its applications to drive value-added transformations under mild, clean and sustainable conditions and also addressed mechanistic aspects. This ED approach will enable and provide inspiration for future applications in electro-organic synthesis.

中文翻译：

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通过 Kolbe 和相关的非 Kolbe 电解进行有机合成：一种使能的电策略

一种高效且环保的合成方法优于需要昂贵的化学品和氧化剂来实现增值有机转化的传统方法。电化学转化遇到了传统的缺点，并引入了简单的放大方法来合成复杂的受阻分子，利用电作为清洁试剂和催化实体。电化学条件最大限度地减少了废物的形成，并增加了在环境条件下获得最大量目标产物的机会。Kolbe 和相关的非 Kolbe 电解过程，其中羧酸的阳极氧化导致脱羧，可以智能地用于形成新键并获得增值分子和立体选择性产品。手性的记忆，我们做出了贡献，通过电化学脱羧（ED）。除此之外，偶联（同源、异源）、二聚化、加成、环化和通过ED激活 CH也是该策略的重要方面。使用 ED 策略的流动电化学和光化学可以提高选择性和产品收率，避免过度氧化。在此，我们讨论了 ED 的几个例子及其在温和、清洁和可持续条件下推动增值转型的应用，并解决了机械方面的问题。这种 ED 方法将为未来在有机电合成中的应用提供灵感。