Trends in Immunology ( IF 16.8 ) Pub Date : 2021-05-31 , DOI: 10.1016/j.it.2021.05.006 Khaled Zubeidat 1 , Avi-Hai Hovav 1
The first encounter of mucosal barriers with the microbiota initiates host–microbiota feedback loops instructing the tailored development of both the immune system and microbiota at each mucosal site. Once established, balanced immunological interactions enable symbiotic relationships with the microbiota in adult life. This process has been extensively investigated in the mammalian monolayer epithelium-covered intestine and lung mucosae; however, the postnatal mechanisms engaged by the oral mucosa to establish homeostasis are currently being discovered. Here, we discuss the early life dialogue between the oral mucosa and the microbiota, with particular emphasis on the central role the multilayer epithelium plays to protect the oral mucosa. These intricate and unique postnatal immunological processes shape oral homeostasis, which can potentially affect buccal and systemic health in adult life.
中文翻译:
由上皮形成——口腔内稳态的出生后免疫机制
粘膜屏障与微生物群的第一次相遇启动了宿主 - 微生物群反馈回路,指导每个粘膜部位的免疫系统和微生物群的定制发展。一旦建立,平衡的免疫相互作用就能与成年生活中的微生物群建立共生关系。这个过程已经在哺乳动物单层上皮覆盖的肠和肺粘膜中进行了广泛的研究。然而,目前正在发现口腔黏膜参与建立体内平衡的出生后机制。在这里,我们讨论口腔黏膜和微生物群之间的早期生命对话,特别强调多层上皮在保护口腔黏膜方面发挥的核心作用。这些复杂而独特的出生后免疫过程塑造了口腔内稳态,