During autophagy, proteins of the ATG8 family are conjugated to phosphatidylethanolamine (PE) in double-membrane structures called phagophores. Now, Durgan et al. have found that, during the non-canonical process of conjugating ATG8 proteins to single-membrane structures, ATG8 can be ligated to phosphatidylserine. Here, I discuss the potential consequences of their findings.

中文翻译：

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自噬工厂的另类职业

在自噬过程中，ATG8 家族的蛋白质在称为吞噬细胞的双膜结构中与磷脂酰乙醇胺 (PE) 结合。现在，Durgan等人。已经发现，在将 ATG8 蛋白结合到单膜结构的非规范过程中，ATG8 可以与磷脂酰丝氨酸连接。在这里，我将讨论他们的发现的潜在后果。