Amoxicillin (AMX) is the most commonly used antibiotic in life. AMX was extracted from aqueous solution by synergetic carrier emulsion liquid membrane (ELM) technology for the first time. The membrane phase of ELM was mainly composed of kerosene and butyl acetate. The carrier has consisted of Aliquat-336 and TOA, the surfactant was Span-80, and the membrane enhancer was liquid paraffin. And Na₂CO₃ and NaCl were used as the internal aqueous phase for extraction. Firstly, the basic structure and mechanism of emulsion were characterized and analyzed. And then, the center composite design (CCD) of response surface methodology (RSM) was used to optimize the operating conditions. The optimal values were: Aliquat-336 concentration (1.1% v/v), trioctylamine (TOA) concentration (8.6% v/v), and extraction time (15 min), AMX concentration (75 mg/L). A polynomial model was fitted to predict the extraction yield of AMX. Under the optimal operating conditions, the optimal extraction prediction value was 98.58%, the extraction actual value was 98.2%, and the recovery rate of AMX was 75.3%.

阿莫西林（AMX）是生活中最常用的抗生素。首次采用协同载体乳液液膜（ELM）技术从水溶液中提取AMX。ELM的膜相主要由煤油和乙酸丁酯组成。载体为Aliquat-336和TOA，表面活性剂为Span-80，膜增强剂为液体石蜡。和 Na ₂ CO ₃和 NaCl 用作萃取的内水相。首先对乳液的基本结构和作用机理进行了表征和分析。然后，采用响应面法（RSM）的中心复合设计（CCD）优化操作条件。最佳值是：Aliquat-336 浓度 (1.1% v/v)、三辛胺 (TOA) 浓度 (8.6% v/v)、萃取时间 (15 分钟)、AMX 浓度 (75 mg/L)。拟合多项式模型来预测 AMX 的提取率。在最佳操作条件下，最佳萃取预测值为98.58%，萃取实际值为98.2%，AMX的回收率为75.3%。