The processes that determine the establishment of the complex morphology of neurons during development are still poorly understood. Here, we focus on the question how a difference in the length of neurites affects vesicle transport. We performed live imaging experiments and present a lattice-based model to gain a deeper theoretical understanding of intracellular transport in neurons. After a motivation and appropriate scaling of the model we present numerical simulations showing that initial differences in neurite length result in phenomena of biological relevance, i.e. a positive feedback that enhances transport into the longer neurite and oscillation of vesicles concentrations that can be interpreted as cycles of extension and retraction observed in experiments. Thus, our model is a first step towards a better understanding of the interplay between the transport of vesicles and the spatial organization of cells.

在发育过程中决定神经元复杂形态建立的过程仍然知之甚少。在这里，我们关注神经突长度的差异如何影响囊泡运输的问题。我们进行了实时成像实验并提出了一个基于晶格的模型，以获得对神经元细胞内转运的更深入的理论理解。在对模型进行动机和适当缩放后，我们提出了数值模拟，表明神经突长度的初始差异会导致生物学相关现象，即增强向较长神经突的转运和囊泡浓度振荡的正反馈，这可以解释为循环实验中观察到的伸展和收缩。因此，