Sesuvium sesuvioides (Fenzl) Verdc is traditionally used in the treatment of inflammatory diseases such as arthritis and gout The aim of present study was to assess the possible anti-inflammatory, analgesic and antipyretic potential of the methanol extract of Sesuvium sesuvioides (SsCr) to prove scientifically its folklore use in the inflammatory diseases and to screen its total antioxidant capacity by multiple methods and phytocompounds by GC–MS. The preliminary phytochemical studies showed the presence of phenols, flavonoids, glycosides, coumarin, terpenoids, saponins, fats and carbohydrates in crude extract. The total phenolic contents (27.31 ± 0.28 mg GAE/g) and total flavonoids (3.58 ± 0.12 mgRE/g) values were observed. The antioxidant capacity of SsCr showed significant DPPH, ABTS, CUPRAC, FRAP, PBD and metal chelating results. GC–MS analysis displayed the phytoconstituents with anti-inflammatory potentials such as 2-methoxy-4-vinylphenol, vanillin, umbelliferone, methyl ferulate, palmitoleic acid, methyl palmitate and phytol. SsCr presented noteworthy HRBC membrane stability with maximum inhibition of cell hemolysis (47.79%). In carrageenan-induced hind paw edema assay result showed dose-dependent anti-inflammatory action. SsCr presented significant (p < 0.05) analgesic activity in hot-plate and tail flicking tests similarly it also showed the noteworthy inhibition in pain latency against formalin induced analgesia at 1st and 2nd phases. SsCr reduced the acetic acid-induced writhes at different doses (250, 500 and 750 mg). Results of antipyretic activity of SsCr extract were significant at 500 and 750 mg. The results of in vitro and in vivo experimental studies verified the anti-inflammatory, analgesic and antipyretic potential of Sesuvium sesuvioides and supported the folklore uses of this plant.

Graphic abstract

中文翻译：

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Sesuvium sesuvioides (Fenzl) Verdc 的植物化学分析、体外和体内抗炎、镇痛和解热潜力。(番荔枝科)

Sesuvium sesuvioides (Fenzl) Verdc 传统上用于治疗关节炎和痛风等炎症性疾病 本研究的目的是评估Sesuvium sesuvioides甲醇提取物可能的抗炎、镇痛和解热潜力(SsCr) 以科学地证明其民间传说在炎症性疾病中的用途，并通过多种方法和 GC-MS 筛选其总抗氧化能力。初步植物化学研究表明，粗提取物中存在酚类、黄酮类化合物、糖苷类、香豆素、萜类化合物、皂苷、脂肪和碳水化合物。观察到总酚含量 (27.31 ± 0.28 mg GAE/g) 和总黄酮 (3.58 ± 0.12 mgRE/g) 值。SsCr 的抗氧化能力显示出显着的 DPPH、ABTS、CUPRAC、FRAP、PBD 和金属螯合结果。GC-MS 分析显示了具有抗炎潜力的植物成分，例如 2-甲氧基-4-乙烯基苯酚、香草醛、伞形酮、阿魏酸甲酯、棕榈油酸、棕​​榈酸甲酯和植醇。SsCr 表现出值得注意的 HRBC 膜稳定性，最大​​程度地抑制细胞溶血 (47.79%)。在角叉菜胶诱导的后爪水肿试验中，结果显示出剂量依赖性抗炎作用。SsCr 表现出显着 (p  < 0.05) 热板和甩尾试验中的镇痛活性类似地，它还显示出在第 1 和第 2 阶段对福尔马林诱导镇痛的疼痛潜伏期的显着抑制。SsCr 在不同剂量（250、500 和 750 毫克）下减少了醋酸引起的扭体。SsCr 提取物的解热活性结果在 500 和 750 毫克时显着。体外和体内实验研究的结果证实了Sesuvium sesuvioides的抗炎、镇痛和解热潜力，并支持该植物的民间传说用途。

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