A time-resolved experimental–mathematical model for predicting the response of glioma cells to single-dose radiation therapy,Integrative Biology

当前位置： X-MOL 学术 › Integr. Biol. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

A time-resolved experimental–mathematical model for predicting the response of glioma cells to single-dose radiation therapy
Integrative Biology ( IF 2.5 ) Pub Date : 2021-06-01 , DOI: 10.1093/intbio/zyab010
Junyan Liu ₁ , David A Hormuth _{2,

3} , Tessa Davis ₁ , Jianchen Yang ₁ , Matthew T McKenna ₄ , Angela M Jarrett _{2,

3} , Heiko Enderling _{5,

6,

7} , Amy Brock _{1,

3,

8} , Thomas E Yankeelov _{1,

2,

3,

7,

8,

9}

Affiliation

Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX 78712, USA.
Oden Institute for Computational Engineering and Sciences, The University of Texas at Austin, Austin, TX 78712, USA.
Livestrong Cancer Institutes, The University of Texas at Austin, Austin, TX 78712, USA.
Department of Surgery, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Department of Integrated Mathematical Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA.
Department of Integrated Radiation Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA.
Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Department of Oncology, The University of Texas at Austin, Austin, TX 78712, USA.
Department of Diagnostic Medicine, The University of Texas at Austin, Austin, TX 78712, USA.

To develop and validate a mechanism-based, mathematical model that characterizes 9L and C6 glioma cells’ temporal response to single-dose radiation therapy in vitro by explicitly incorporating time-dependent biological interactions with radiation.

中文翻译：