Adjuvant radiotherapy (RT) for breast cancer (BC) has been associated with an increased risk of later radiation-induced lung cancer (LC). We examined the risk of primary LC in a population-based cohort of 52300 women treated for BC during 1992 to 2012, and 253796 age-matched women without BC. Cumulative incidence of LC was calculated by the Kaplan–Meier method, and the risk of LC after BC treatment was estimated by Cox proportional hazards regression analyses. Women with BC receiving RT had a higher cumulative incidence of LC compared to women with BC not receiving RT and women without BC. This became apparent 5 years after RT and increased with longer follow-up. Women with BC receiving RT had a Hazard ratio of 1.59 (95% confidence interval 1.37–1.84) for LC compared to women without BC. RT techniques that lower the incidental lung doses, e.g breathing adaption techniques, may lower this risk.

乳腺癌 (BC) 的辅助放疗 (RT) 与后期辐射诱发的肺癌 (LC) 的风险增加有关。我们检查了 1992 年至 2012 年期间接受 BC 治疗的 52300 名女性和 253796 名年龄匹配的无 BC 女性的基于人群的队列中原发性 LC 的风险。LC 的累积发生率通过 Kaplan-Meier 方法计算，BC 治疗后 LC 的风险通过 Cox 比例风险回归分析估计。与未接受 RT 的 BC 女性和未接受 BC 的女性相比，接受 RT 的 BC 女性的 LC 累积发生率更高。这在放疗后 5 年变得明显，并随着随访时间的延长而增加。与未接受 BC 的女性相比，接受 RT 的 BC 女性患 LC 的风险比为 1.59（95% 置信区间 1.37-1.84）。降低偶然肺剂量的放疗技术，例如。