The aim of this study is to implement lifetime attributable risk (LAR) predictions for radiation induced cancers for Swedish cohorts of patients of various age and sex, undergoing diagnostic investigations by nuclear medicine methods. Methods: Calculations are performed on Swedish groups of patients with Paget's disease and with bone metastases from prostatic cancer and diagnosed with bone scintigraphy with an administration of 500 MBq 99mTc-phosphonate. Results: The inclusion of patient survival rates into the calculations lowers the induced radiation cancer risk, as it takes into account that cohorts of patients have shorter predicted survival times than the general population. Conclusion: LAR estimations could be valuable for referring physicians, nuclear medicine physicians, nurses, medical physicists, radiologists, and oncologists and as well as ethical committees for risk estimates for specific subgroups of patients. Caution is however advised with respect to application of LAR predictions to individuals (because of individual sensitivities, circumstances, etc.).

中文翻译：

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改进了适用于瑞典患者群体的特定年龄和性别的辐射风险模型

本研究的目的是为瑞典不同年龄和性别的患者群体实施辐射诱发癌症的终生归因风险 (LAR) 预测，并通过核医学方法进行诊断调查。方法：对瑞典的佩吉特病和前列腺癌骨转移患者组进行计算，并通过骨闪烁扫描诊断为给予 500 MBq 99mTc-膦酸盐。结果：将患者生存率纳入计算可降低诱发辐射癌症的风险，因为它考虑到患者队列的预测生存时间比一般人群短。结论：LAR 估计对于转诊医师、核医学医师、护士、医学物理学家、放射科医师、和肿瘤学家以及伦理委员会对特定患者亚组进行风险评估。然而，在将 LAR 预测应用于个人时要谨慎（因为个人敏感性、环境等）。