Mutations activating the hedgehog (Hh) signalling pathway have been described in anterior skull base meningiomas, raising hope for the use of targeted therapies. However, identification of Hh-activated tumours is hampered by the lack of a reliable immunohistochemical marker. We report the evaluation of GAB1, an immunohistochemical marker used to detect Hh pathway activation in medulloblastoma, as a potential marker of Hh-activated meningiomas.

中文翻译：

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GAB1 过表达识别刺猬激活的前颅底脑膜瘤

已经在前颅底脑膜瘤中描述了激活刺猬 (Hh) 信号通路的突变，这为使用靶向治疗带来了希望。然而，由于缺乏可靠的免疫组织化学标志物，Hh 激活肿瘤的鉴定受到了阻碍。我们报告了 GAB1 的评估，GAB1 是一种用于检测髓母细胞瘤中 Hh 通路激活的免疫组织化学标记物，作为 Hh 激活的脑膜瘤的潜在标记物。