Sesamolin is one of the lignans derived from sesame oil. It has demonstrated significant antioxidant, anti-aging, and anti-mutagenic properties. It also reportedly augments natural killer (NK) cell lysis activity. We previously reported that sesamolin also exerts anticancer effects in vitro and induces enhanced NK cell cytolytic activity against tumor cells. Herein, we aimed to determine the mechanism by which sesamolin prevents and retards tumorigenesis in BALB/c mouse models of leukemia induced by murine (BALB/c) myelomonocytic leukemia WEHI-3B cells. Banded neutrophils, myeloblasts, and monocytic leukemic cells were more abundant in the leukemia model than in normal mice. Sesamolin decreased the number of leukemic cells by almost 60% in the leukemia model mice in vivo; additionally, sesamolin and the positive control drug, vinblastine, similarly hindered neoplastic cell proliferation. Spleen samples were ~ 4.5-fold heavier in leukemic mice than those obtained from normal mice, whereas spleen samples obtained from leukemic mice treated with sesamolin had a similar weight to those of normal mice. Moreover, sesamolin induced a twofold increase in the cytotoxic activity of leukemic mouse NK cells against WEHI-3B cells. These results indicated that sesamolin exerts anti-leukemic effects in vivo.

中文翻译：

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芝麻素对WEHI-3B诱导的模型小鼠白血病的治疗作用

芝麻素是从芝麻油中提取的木脂素之一。它已显示出显着的抗氧化、抗衰老和抗诱变特性。据报道，它还可以增强自然杀伤 (NK) 细胞裂解活性。我们之前报道了芝麻素在体外也发挥抗癌作用，并诱导增强的 NK 细胞对肿瘤细胞的溶细胞活性。在此，我们旨在确定芝麻素在小鼠 (BALB/c) 骨髓单核细胞白血病 WEHI-3B 细胞诱导的 BALB/c 小鼠白血病模型中预防和延缓肿瘤发生的机制。与正常小鼠相比，白血病模型中的带状中性粒细胞、成髓细胞和单核细胞白血病细胞更丰富。在体内白血病模型小鼠中，芝麻素使白血病细胞的数量减少了近 60%；此外，芝麻素和阳性对照药物长春碱，同样阻碍肿瘤细胞增殖。白血病小鼠的脾脏样本比正常小鼠的脾脏样本重约 4.5 倍，而用芝麻素处理的白血病小鼠的脾脏样本与正常小鼠的体重相似。此外，芝麻素诱导白血病小鼠 NK 细胞对 WEHI-3B 细胞的细胞毒活性增加两倍。这些结果表明芝麻素在体内发挥抗白血病作用。