Superior limbic keratoconjunctivitis (SLK) is characterized by chronic inflammation of the superior limbus and superior bulbar and tarsal conjunctivae. Patients also often have fine punctate staining of the limbus and adjacent area, superior limbic proliferation seen as thickening of the limbal epithelium and surrounding conjunctiva, and occasionally filaments at the superior limbus and upper cornea. SLK frequently presents with ocular irritation, foreign body sensation, and photophobia. SLK can be associated with other ocular and non-ocular conditions, such as thyroid disease. Although the pathogenesis of SLK is still unknown, it is thought to be related to mechanical injury, tear film instability, or an autoimmune/inflammatory etiology. Many patients with SLK can be asymptomatic or have symptoms that resolve or remit spontaneously. For symptomatic SLK, patients are managed medically with treatments such as lubricants, topical anti-inflammatory or immunomodulatory medications, punctal occlusion, and bandage contact lenses. Patients with symptoms refractory to medical management may need surgical interventions. We detail the current literature on the epidemiology, clinical manifestations, associated conditions, histopathology, pathogenesis, and treatment of SLK.

上缘角膜结膜炎 (SLK) 的特征是上缘和上球结膜和睑结膜的慢性炎症。患者的角膜缘和邻近区域也常有细小的点状染色，上缘增生表现为角膜缘上皮和周围结膜增厚，偶尔在上缘和角膜上部有细丝。SLK 常表现为眼部刺激、异物感和畏光。SLK 可能与其他眼部和非眼部疾病有关，例如甲状腺疾病。虽然 SLK 的发病机制尚不清楚，但被认为与机械损伤、泪膜不稳定或自身免疫/炎症病因有关。许多 SLK 患者可能无症状或症状可自行消退或缓解。对于有症状的 SLK，患者通过润滑剂、局部抗炎或免疫调节药物、泪点闭塞和绷带隐形眼镜等治疗进行医疗管理。对药物治疗有顽固症状的患者可能需要手术干预。我们详细介绍了当前关于 SLK 的流行病学、临床表现、相关病症、组织病理学、发病机制和治疗的文献。