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Long noncoding RNA ENST00000508435 promotes migration of breast cancer via FXR 1
Cell Adhesion & Migration ( IF 3.2 ) Pub Date : 2021-05-30 , DOI: 10.1080/19336918.2021.1921402
Luying Li 1, 2 , Youping Jin 1 , Xue Wang 1 , Li Wang 2, 3 , Yangbai Sun 4 , Yihong Luo 5 , Xiaojian Ni 5 , Qi Lu 1 , Wenbo Wei 2 , Xiuling Zhi 1 , Jerry Yu 6 , Wei Zhu 5 , Ping Zhou 1
Affiliation  

ABSTRACT

LncRNA plays a critical role in tumor progression. However, the role it executes in breast cancer is still unclear. Here, we report a newly discovered lncRNA, ENST00000508435, which could be remarkably up-regulated in breast cancer cells and tissues. We found that the expression of ENST00000508435 was positively correlated with tumor size, lymph node metastasis and HER2. More interesting, overexpression of ENST00000508435 significantly increased cell migration, while specific knockdown led to the opposite. RNA pull-down and RNA immunoprecipitation assays demonstrated that ENST00000508435 could directly bind to FXR1 to promote tumor metastasis. ENST00000508435 and FXR1 were positively correlated. FXR1 was also significantly up-regulated in breast tumors. Taken together, we propose that ENST00000508435 regulates FXR1 to promote breast cancer metastasis.



中文翻译:

长链非编码 RNA ENST00000508435 通过 FXR 1 促进乳腺癌的迁移

摘要

LncRNA 在肿瘤进展中起关键作用。然而,它在乳腺癌中的作用仍不清楚。在这里,我们报告了一种新发现的 lncRNA,ENST00000508435,它可以在乳腺癌细胞和组织中显着上调。我们发现ENST00000508435的表达与肿瘤大小、淋巴结转移和HER2呈正相关。更有趣的是,ENST00000508435 的过表达显着增加了细胞迁移,而特定的敲低导致相反的结果。RNA 下拉和 RNA 免疫沉淀试验表明,ENST00000508435可以直接与 FXR1 结合以促进肿瘤转移。ENST00000508435和 FXR1 呈正相关。FXR1 在乳腺肿瘤中也显着上调。总之,我们建议ENST00000508435调节 FXR1 以促进乳腺癌转移。

更新日期:2021-05-31
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