Layered rare earth hydroxides (LRHs) due to outstanding photoluminescence (PL) properties and anion exchangeability are extensively reported in multiple fields. In this work, the drug-loaded and bactericidal behaviors of Eu³⁺-doped layered gadolinium hydroxides (LGdHs:Eu) as optical carriers were explored through intercalation and release of cephalexin (CE). In the intercalation state, the PL intensity of CEˉ-LGdHs:Eu obviously decreased because of the quenching effect of CEˉ. And the PL intensity of LGdHs:Eu was restored with the release of CEˉ ions in phosphate buffer solutions (PBS). A significant functional relationship between the drug releasing amount and PL intensity ratio was found, providing a novel optical method to specify the drug dosage. And CEˉ-LGdHs:Eu showed the excellent bactericidal properties in both in vivo and in vitro experiments.

由于出色的光致发光 (PL) 特性和阴离子交换性，层状稀土氢氧化物 (LRH) 在多个领域被广泛报道。在这项工作中，Eu ^{3+ 的}载药和杀菌行为通过头孢氨苄 (CE) 的嵌入和释放，探索了作为光学载体的掺杂层状氢氧化钆 (LGdHs:Eu)。在嵌入状态下，CEˉ-LGdHs:Eu的PL强度由于CEˉ的猝灭效应而明显降低。并且 LGdHs:Eu 的 PL 强度随着 CEˉ 离子在磷酸盐缓冲溶液 (PBS) 中的释放而恢复。发现药物释放量与PL强度比之间存在显着的函数关系，为指定药物剂量提供了一种新的光学方法。CEˉ-LGdHs:Eu在体内外实验中均表现出优异的杀菌性能。