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A critical review of palladium organometallic anticancer agents
Cell Reports Physical Science ( IF 8.9 ) Pub Date : 2021-05-31 , DOI: 10.1016/j.xcrp.2021.100446
Thomas Scattolin , Vladislav A. Voloshkin , Fabiano Visentin , Steven P. Nolan

With the aim of overcoming the well-known limitations of platinum-based antineoplastic drugs, recent efforts have focused on the development of new anticancer agents containing metals other than platinum. Among these agents, organopalladium compounds have received significant recent attention due to their generally high stability under physiological conditions. A significant number of these compounds have shown promising in vitro and in vivo antiproliferative activity toward several cisplatin-sensitive and cisplatin-resistant tumors and have sometimes exhibited a different mechanism of action compared to platinum-based drugs. In this review, recent advances in the field of organopalladium compounds as potential anticancer agents are discussed.



中文翻译:

钯有机金属抗癌剂的批判性评论

为了克服众所周知的铂类抗肿瘤药物的局限性,最近的努力集中在开发含有铂以外金属的新型抗癌剂上。在这些试剂中,有机钯化合物由于其在生理条件下通常具有高稳定性而最近受到了极大的关注。大量这些化合物已显示出对几种顺铂敏感性和顺铂耐药性肿瘤的体外体内抗增殖活性,并且与铂类药物相比,有时表现出不同的作用机制。在这篇综述中,讨论了有机钯化合物作为潜在抗癌剂领域的最新进展。

更新日期:2021-06-23
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