ABSTRACT

The mineralisation and ion release behaviour of the bioactive glasses play a crucial role for their biomedical applications. It is, however, difficult to control these processes artificially in situ. Herein we utilised NIR radiation as an external stimuli to tailor these processes to match specific requirements. Therefore, the composite bone cements based on borosilicate glass incorporated with TiN NPs were fabricated. It is found that, under 1064 nm laser irradiation, the composite bone cements exhibited remarkable photothermal performance and the cumulative amount of silicon, boron and calcium ions of the composite bone cement increased by 4.74, 1.79, and 1.26 times within 10 days, respectively. Even at the later stage of mineralisation, the ions release rates could be accelerated. Additionally, 1064 nm laser irradiation accelerated the formation of HA. Therefore, this paper provided an effective way to regulate the mineralisation and ion release behaviour of bioactive glass after implantation.

摘要

生物活性玻璃的矿化和离子释放行为对其生物医学应用起着至关重要的作用。然而，很难在现场人为地控制这些过程。在这里，我们利用 NIR 辐射作为外部刺激来调整这些过程以满足特定要求。因此，制备了基于硼硅酸盐玻璃和 TiN NPs 的复合骨水泥。结果表明，在1064 nm激光照射下，复合骨水泥表现出显着的光热性能，10天内复合骨水泥的硅、硼和钙离子累积量分别增加了4.74、1.79和1.26倍。即使在矿化后期，离子释放速度也可以加快。此外，1064 nm 激光照射加速了 HA 的形成。因此，本文为调节生物活性玻璃植入后的矿化和离子释放行为提供了一种有效途径。