Retention durability, especially in the eye, is one of the most important properties of ophthalmic viscosurgical devices (OVDs) during ocular surgery. However, the information on the physical properties of OVDs is insufficient to explain their retention durability. The purpose of this study is to clarify the mechanism of OVD retention to improve understanding of the behavior of OVDs during ocular surgery. To elucidate the mechanism of OVD retention, we have developed a new test method for measuring repulsive force. As a result, the maximum repulsive force of OVDs was positively and well correlated with the retention durability of investigated OVDs. Consequently, we demonstrated that the repulsive force could be used as an index of retention durability on the ocular surface and in the eye. We directly compared the intraocular retention durability of three OVDs (Shellgan, Viscoat, and Opegan-Hi) in ex vivo porcine eyes. Opegan-Hi was immediately removed from the anterior chamber, but Shellgan and Viscoat remained largely in the anterior chamber as determined by fluorescence imaging. These results showed that the intraocular retention behavior of OVDs was similar to their ocular surface behavior in our previous report, suggesting that retention durability is dependent on the OVD itself. The retention durability of Shellgan seemed to be higher than that of Viscoat, and the maximum repulsive force of Shellgan was 1.35-fold higher than that of Viscoat. Therefore, the repulsive force might be a useful index for assessing the difference in the retention durability between OVDs such as Shellgan and Viscoat.

保留耐久性，尤其是在眼睛中，是眼科手术过程中眼科粘稠外科装置 (OVD) 最重要的特性之一。然而，关于 OVD 物理特性的信息不足以解释它们的保持耐久性。本研究的目的是阐明 OVD 保留的机制，以提高对眼科手术过程中 OVD 行为的理解。为了阐明 OVD 保留的机制，我们开发了一种新的测试方法来测量排斥力。因此，OVD 的最大排斥力与所研究的 OVD 的保持耐久性呈正相关且密切相关。因此，我们证明了排斥力可以用作眼表和眼睛中保留耐久性的指标。离体猪眼。Opegan-Hi 立即从前房中取出，但根据荧光成像确定，Shellgan 和 Viscoat 大部分仍留在前房中。这些结果表明，OVD 的眼内滞留行为与我们之前报告中的眼表行为相似，表明滞留持久性取决于 OVD 本身。Shellgan的保持耐久性似乎高于Viscoat，Shellgan的最大排斥力是Viscoat的1.35倍。因此，排斥力可能是评估 OVD（如 Shellgan 和 Viscoat）之间保持耐久性差异的有用指标。