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Antiviral strategies targeting herpesviruses
Journal of Virus Eradication ( IF 5.1 ) Pub Date : 2021-05-30 , DOI: 10.1016/j.jve.2021.100047
Haisi Dong 1 , Zeyu Wang 1 , Daqing Zhao 1 , Xiangyang Leng 1 , Yicheng Zhao 1
Affiliation  

Herpesviruses, known as large DNA viruses, have a wide host range. In addition to human beings, cattle, and horses, even carp can be hosts for herpesvirus infection. Herpesviruses are pathogens possessing elaborate mechanisms that regulate host cell components for its replication, assembly and generating mature virus particles that can infect humans and most animals, usually causing multiple and lifelong infections. In addition, several human diseases, such as genital or mouth herpes, mononucleosis, and Burkitt lymphoma, are usually associated with herpesvirus infection. Blocking the steps of viral infection, such as entry, replication and assembly, may be an effective way for many different herpes viruses and their related diseases. Therefore, we aim to describe antiviral agents that are able to prevent herpesvirus entry, replication and assembly in host cells. We summarize antiviral strategies, including certain small molecular drugs, RNA interference and CRISPR/Cas9 system-based antiviral approaches, which represent promising approaches.



中文翻译:

针对疱疹病毒的抗病毒策略

疱疹病毒,被称为大 DNA 病毒,具有广泛的宿主范围。除了人、牛、马,甚至鲤鱼也可以成为疱疹病毒感染的宿主。疱疹病毒是一种病原体,拥有复杂的机制,可以调节宿主细胞成分的复制、组装和产生成熟的病毒颗粒,这些颗粒可以感染人类和大多数动物,通常会引起多次和终生感染。此外,一些人类疾病,例如生殖器或口腔疱疹、单核细胞增多症和伯基特淋巴瘤,通常与疱疹病毒感染有关。阻断病毒感染的进入、复制、组装等步骤,可能是许多不同疱疹病毒及其相关疾病的有效途径。因此,我们的目标是描述能够防止疱疹病毒进入的抗病毒药物,在宿主细胞中复制和组装。我们总结了抗病毒策略,包括某些小分子药物、RNA 干扰和基于 CRISPR/Cas9 系统的抗病毒方法,它们代表了有前景的方法。

更新日期:2021-06-05
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