Decidual natural killer cells (dNK), the predominant decidual lymphocytes in early pregnancy, are primarily identified based on their CD56^bright CD16⁻ phenotype and play an important role in maintaining immune tolerance at the maternal–fetal interface. dNK dysfunction reportedly leads to pathological pregnancy. Indeed, various dNK-derived soluble factors are involved in a series of key processes related to pregnancy outcomes. In this review, we summarize the roles of these dNK-derived factors in immune tolerance and embryonic development to improve the current understanding regarding the physiological and pathological mechanisms that occur during pregnancy, while potentially informing the development of effective therapeutics.

中文翻译：

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蜕膜自然杀伤细胞衍生可溶性因子在妊娠早期的作用

蜕膜自然杀伤细胞 (dNK) 是妊娠早期的主要蜕膜淋巴细胞，主要根据其 CD56^亮CD16 ^-表型进行鉴定，并在维持母胎界面的免疫耐受中发挥重要作用。据报道，dNK 功能障碍会导致病理性妊娠。事实上，各种 dNK 衍生的可溶性因子参与了一系列与妊娠结果相关的关键过程。在这篇综述中，我们总结了这些 dNK 衍生因子在免疫耐受和胚胎发育中的作用，以提高目前对妊娠期间发生的生理和病理机制的理解，同时可能为有效治疗方法的开发提供信息。