Xpert Xpress Flu/RSV is a fast and automated real-time nucleic acid amplification tool for detecting influenza virus and respiratory syncytial virus (RSV). The aim of this study was to verify the accuracy of Xpert Xpress Flu/RSV in detecting influenza virus and RSV. PubMed, EMBASE, Cochrane Library, and Web of Science were searched up to October 2020. The quality of original research was assessed using the Quality Assessment of Diagnostic Accuracy Studies-2 guidelines. Meta-DiSc 1.4 software was used to analyze the sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, diagnostic odds ratio, and Summary receiver operating characteristic curve. Deek’s funnel plot asymmetry test was used to evaluate the publication bias by Stata 12.0. Ten studies with 25 fourfold tables were included in this analysis. The sensitivity of Xpert Xpress Flu/RSV in detecting influenza A, influenza B, and RSV was 0.97, 0.98, 0.96, respectively, and the specificity was 0.97, 1.00, 1.00, respectively. Compared with other common clinical real-time reverse transcriptase PCR (RT-PCR), Xpert Xpress Flu/RSV is a valuable tool for diagnosing influenza virus and RSV with high sensitivity and specificity.

Xpert Xpress Flu/RSV 是一种快速、自动化的实时核酸扩增工具，用于检测流感病毒和呼吸道合胞病毒 (RSV)。本研究的目的是验证 Xpert Xpress Flu/RSV 检测流感病毒和 RSV 的准确性。 检索了截至 2020 年 10 月的 PubMed、EMBASE、Cochrane 图书馆和 Web of Science。使用诊断准确性研究的质量评估-2 指南评估原始研究的质量。Meta-DiSc 1.4软件用于分析敏感性、特异性、阳性似然比、阴性似然比、诊断优势比和汇总接收者操作特征曲线。Deek 的漏斗图不对称检验用于评估 Stata 12.0 的发表偏倚。 该分析包括 10 项具有 25 个四重表的研究。Xpert Xpress Flu/RSV检测甲型流感、乙型流感和RSV的敏感性分别为0.97、0.98、0.96，特异性分别为0.97、1.00、1.00。与其他常见的临床实时逆转录酶 PCR (RT-PCR) 相比，Xpert Xpress Flu/RSV 是诊断流感病毒和 RSV 的一种有价值的工具，具有高灵敏度和特异性。