The development of plant tissues requires cell–cell communication facilitated by chemical and peptide hormones, including small signaling peptides in the CLAVATA3/EMBRYO-SURROUNDING REGION (CLE) family. The paradigmatic CLE signaling peptide CLAVATA3 regulates the size of the shoot apical meristem and the expression of the stem cell–promoting WUSCHEL transcription factor through an unknown mechanism. This review discusses recent advances in CLE signaling, showing that CLE pathways are conserved in bryophytes, that CLE peptides in Arabidopsis thaliana regulate stem cell identity and cell division in root tissues, and connections to auxin biosynthesis in regulating flower and leaf development. These advances shed light on potential WUSCHEL family–independent aspects of CLE signaling and the overlap between CLE and auxin signaling

植物组织的发育需要由化学和肽激素促进的细胞间通讯，包括CLAVATA3/EMBRYO-SURROUNDING REGION ( CLE)家族中的小信号肽。典型的 CLE 信号肽 CLAVATA3通过未知机制调节茎尖分生组织的大小和促进干细胞的WUSCHEL转录因子的表达。这篇综述讨论了 CLE 信号传导的最新进展，表明 CLE 途径在苔藓植物中是保守的，拟南芥中的 CLE 肽调节根组织中的干细胞特性和细胞分裂，以及与生长素生物合成的连接在调节花和叶发育中。这些进展揭示了潜力WUSCHEL家族独立方面的 CLE 信号以及 CLE 和生长素信号之间的重叠