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Respiratory mechanics during methacholine bolus and continuous infusion protocols in asthma model
Respiratory Physiology & Neurobiology ( IF 2.3 ) Pub Date : 2021-05-29 , DOI: 10.1016/j.resp.2021.103705
Renato Lima Vitorasso 1 , Maria Aparecida Oliveira 2 , Wothan Tavares-de-Lima 2 , Henrique Takachi Moriya 1
Affiliation  

Balb/c mice respiratory mechanics was studied in two intravenous methacholine (MCh) protocols: bolus and continuous infusion. The Constant Phase Model (CPM) was used in this study. The harmonic distortion index (kd) was used to assess the respiratory system nonlinearity. The analysis of variance showed difference between groups (OVA vs control) and among doses for both protocols. Bolus protocol posttest: there was a difference between OVA and control at 0.3 and 1 mg/kg doses (p<0.0001 and p<0.001) for Rn. Infusion: there was a difference between OVA and control at 192 μg.kg−1.min−1 dose for Rn, G and H, (p<0.01; p<0.001; p<0.001). An increment was found in kd values near to the observed peak values in bolus protocol. The bolus protocol could better differentiate inflamed and non-inflamed airway resistance, whereas the differences between OVA and control in continuous infusion protocol were associated to airway- and, mainly, parenchyma-related parameters. Moreover, the bolus protocol presented a higher nonlinear degree compared to the infusion protocol.



中文翻译:

哮喘模型中乙酰甲胆碱推注和连续输注方案期间的呼吸力学

在两种静脉注射乙酰甲胆碱 (MCh) 方案中研究了 Balb/c 小鼠的呼吸力学:推注和连续输注。本研究使用恒定相位模型 (CPM)。谐波失真指数 (ķd) 用于评估呼吸系统的非线性。方差分析显示两组(OVA 与对照)之间以及两种方案的剂量之间存在差异。推注方案后测:在 0.3 和 1 mg/kg 剂量(p<0.0001 和 p<0.001)的 OVA 和对照之间存在差异Rn. 输注:OVA 和对照在 192 μg.kg -1 .min -1剂量下存在差异Rn, GH, (p<0.01;p<0.001;p<0.001)。发现一个增量ķd接近推注方案中观察到的峰值的值。推注方案可以更好地区分发炎和非发炎的气道阻力,而连续输注方案中 OVA 和对照之间的差异与气道相关,主要与实质相关参数有关。此外,与输注方案相比,推注方案呈现出更高的非线性程度。

更新日期:2021-06-01
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