Acute cannabis intoxication may induce neurocognitive impairment and is a possible cause of human error, injury and psychological distress. One of the major concerns raised about increasing cannabis legalization and the therapeutic use of cannabis is that it will increase cannabis‐related harm. However, the impairing effect of cannabis during intoxication varies among individuals and may not occur in all users. There is evidence that the neurocognitive response to acute cannabis exposure is driven by changes in the activity of the mesocorticolimbic and salience networks, can be exacerbated or mitigated by biological and pharmacological factors, varies with product formulations and frequency of use and can differ between recreational and therapeutic use. It is argued that these determinants of the cannabis-induced neurocognitive state should be taken into account when defining and evaluating levels of cannabis impairment in the legal arena, when prescribing cannabis in therapeutic settings and when informing society about the safe and responsible use of cannabis.

急性大麻中毒可能会导致神经认知障碍，并可能导致人为错误、伤害和心理困扰。关于增加大麻合法化和大麻治疗用途的主要担忧之一是它会增加与大麻相关的危害。然而，大麻在中毒期间的损害作用因人而异，可能并非所有使用者都会发生。有证据表明，对急性大麻暴露的神经认知反应是由中皮质边缘和显着性网络活动的变化驱动的，可以通过生物和药理因素加剧或减轻，因产品配方和使用频率而异，并且在娱乐和娱乐之间可能有所不同。治疗用途。