Abstract

Osmium (IV) complexes with pyrazole nucleus containing ligands were synthesized. Os(IV) compounds were characterized using ESI-MS, ICP-OES, IR spectroscopy, electronic spectroscopy, conductance, and magnetic measurements. Whereas, ligands were characterized by heteronuclear spectroscopy, (¹H and ¹³C), IR spectroscopy, and elemental analysis. All the compounds were tested for their potential to interact with HS-DNA by absorption titration, fluorescence spectroscopy, viscosity measurement, and docking study. The quenching constant and Stern Volmer constant values were calculated using fluorescence study. The synthesized compounds were studied for in-vitro bacteriostatic and cytotoxic activities. The cancer cell line studies of all the synthesized complexes were carried out on human lung cancer cells (A549).

Supplemental data for this article is available online at https://doi.org/10.1080/15257770.2021.1921795 .

摘要

合成了与含有配体的吡唑核的锇 (IV) 配合物。Os(IV) 化合物使用 ESI-MS、ICP-OES、红外光谱、电子光谱、电导和磁性测量进行表征。而配体的特征在于异核光谱（¹ H 和¹³ C）、IR 光谱和元素分析。通过吸收滴定、荧光光谱、粘度测量和对接研究，测试了所有化合物与 HS-DNA 相互作用的潜力。使用荧光研究计算猝灭常数和 Stern Volmer 常数值。合成的化合物用于体外研究抑菌和细胞毒活性。所有合成复合物的癌细胞系研究均在人肺癌细胞 (A549) 上进行。

本文的补充数据可在 https://doi.org/10.1080/15257770.2021.1921795 在线获得。