Hyperglycemia-induced oxidative stress has been implicated in diabetes and its complications. Medicinal plants possessing antioxidant activity may decrease oxidative stress by scavenging radicals and reducing power activity and would be a promising strategy for the treatment of inflammatory disorders like diabetes. This study was designed to evaluate the antioxidant effect of Aqueous Extract of S.coccinea leaf (AESL) in HG treated THP-1 cells and streptozotocin (STZ)-induced diabetic Wistar rats. AESL and the standard antidiabetic drug glibenclamide were administered orally by intragastric tube for 14 days and pre-treated HG grown THP-1 cells. AESL treatment reduced HG induced increase in ROS production, NF-κB dependent proinflammatory gene expression by influencing NF-κB nuclear translocation in THP-1 cells. Oral administration of AESL inhibited STZ-induced increase in serum lipid peroxidation, aspartate transaminase, alanine transaminase, and Lactate dehydrogenase of diabetic rats. Significant increase in activity of superoxide dismutase, catalase and glutathione peroxidase, and a reduced level of glutathione, were observed in AESL treatment. The results demonstrate that AESL is useful in controlling blood glucose and also has antioxidant potential to influence the translocation of NF-κB, protect damage caused by hyperglycemia-induced inflammation.

高血糖诱导的氧化应激与糖尿病及其并发症有关。具有抗氧化活性的药用植物可以通过清除自由基和降低能量活性来降低氧化应激，这将是治疗糖尿病等炎症性疾病的有希望的策略。本研究旨在评估S.coccinea叶水提取物 ( AESL ) 在 HG 处理的 THP-1 细胞和链脲佐菌素 (STZ) 诱导的糖尿病 Wistar 大鼠中的抗氧化作用。AESL和标准抗糖尿病药物格列本脲通过胃内管口服给药 14 天，并预处理 HG 生长的 THP-1 细胞。AESL治疗通过影响 THP-1 细胞中的 NF-κB 核转位来减少 HG 诱导的 ROS 产生增加、NF-κB 依赖性促炎基因表达。口服AESL可抑制STZ诱导的糖尿病大鼠血清脂质过氧化、天冬氨酸转氨酶、丙氨酸转氨酶和乳酸脱氢酶的增加。在AESL处理中观察到超氧化物歧化酶、过氧化氢酶和谷胱甘肽过氧化物酶的活性显着增加，谷胱甘肽水平降低。结果表明，AESL可用于控制血糖，还具有抗氧化潜力，可影响 NF-κB 的易位，保护由高血糖引起的炎症引起的损伤。