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Reduced brain activation during spoken language processing in children with developmental language disorder and children with 22q11.2 deletion syndrome
Neuropsychologia ( IF 2.6 ) Pub Date : 2021-05-28 , DOI: 10.1016/j.neuropsychologia.2021.107907
Mariska J Vansteensel 1 , Iris S Selten 2 , Lisette Charbonnier 1 , Julia Berezutskaya 1 , Mathijs A H Raemaekers 1 , Nick F Ramsey 1 , Frank Wijnen 2
Affiliation  

Language difficulties of children with Developmental Language Disorder (DLD) have been associated with multiple underlying factors and are still poorly understood. One way of investigating the mechanisms of DLD language problems is to compare language-related brain activation patterns of children with DLD to those of a population with similar language difficulties and a uniform etiology. Children with 22q11.2 deletion syndrome (22q11DS) constitute such a population. Here, we conducted an fMRI study, in which children (6-10yo) with DLD and 22q11DS listened to speech alternated with reversed speech. We compared language laterality and language-related brain activation levels with those of typically developing (TD) children who performed the same task. The data revealed no significant differences between groups in language lateralization, but task-related activation levels were lower in children with language impairment than in TD children in several nodes of the language network. We conclude that language impairment in children with DLD and in children with 22q11DS may involve (partially) overlapping cortical areas.



中文翻译:

发育性语言障碍儿童和 22q11.2 缺失综合征儿童口语处理过程中大脑活动减少

发育性语言障碍 (DLD) 儿童的语言困难与多种潜在因素有关,但仍知之甚少。研究 DLD 语言问题机制的一种方法是将 DLD 儿童的语言相关大脑激活模式与具有相似语言困难和统一病因的人群进行比较。患有 22q11.2 缺失综合征 (22q11DS) 的儿童构成了这样的人群。在这里,我们进行了一项 fMRI 研究,其中患有 DLD 和 22q11DS 的儿童(6-10 岁)听到的语音与反向语音交替。我们将语言偏侧性和语言相关的大脑激活水平与执行相同任务的典型发育 (TD) 儿童的水平进行了比较。数据显示各组之间在语言侧化方面没有显着差异,但在语言网络的几个节点中,语言障碍儿童的任务相关激活水平低于 TD 儿童。我们得出结论,DLD 儿童和 22q11DS 儿童的语言障碍可能涉及(部分)重叠的皮质区域。

更新日期:2021-06-05
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