Innate and adaptive immune systems have a crucial role in initiating and progressing some pregnancy disorders such as preeclampsia (PE), which is one of the pregnancy-specific disorders that could result in neonatal and maternal morbidity and mortality. The dysregulation of the spiral artery and inadequate trophoblast invasion lead to PE symptoms through producing various inflammatory cytokines and anti-angiogenic factors from the placenta. T lymphocytes play a special role in the epithelium and stroma of the human endometrium. CD4+ T helper (Th) cells, Th1/Th2, and Th17/T regulatory (Treg) balance mainly contribute to the establishment of a pregnancy-favorable environment. This review examined the dysregulation of some cytokines produced from T cells, the dysregulation of the transcription factors of Th cells, the expression of chemokine receptors on T cells, as well as the effects of some factors including vitamin D on the activity of T cells, and finally, the dysregulation of various miRNAs related to T cells, which could cause PE.

中文翻译：

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T淋巴细胞和先兆子痫：T细胞亚群和相关微小RNA在先兆子痫发病机制中的潜在作用

先天性和适应性免疫系统在引发和发展一些妊娠疾病如先兆子痫 (PE) 中起着至关重要的作用，这是一种妊娠特异性疾病，可能导致新生儿和产妇发病率和死亡率。螺旋动脉的失调和滋养层侵入不足通过从胎盘产生各种炎性细胞因子和抗血管生成因子导致PE症状。T淋巴细胞在人类子宫内膜的上皮和基质中发挥特殊作用。CD4+ T 辅助 (Th) 细胞、Th1/Th2 和 Th17/T 调节 (Treg) 平衡主要有助于建立有利于怀孕的环境。本综述检查了 T 细胞产生的一些细胞因子的失调、Th 细胞转录因子的失调、