In this work, the radiotracer [ 99m Tc]nitrido-oxiracetam complex was labeled in the presence of 99m Tc-nitrido as a core. In order to get the highest radiochemical purity, many effective factors have been studied such as temperature of the reaction, time of the reaction, the pH of the reaction mixture, substrate amount, and stability to give high percent more than 99%. Finally, biodistribution studies have been indicated the convenience of [ 99m Tc]nitrido-oxiracetam as a new radiotracer that could be used in brain imaging. Giving a maximum uptake of 10.6% at 30 min post injection.

中文翻译：

---

99mTc 硝基-奥拉西坦作为脑成像模型的合成、表征和生物评价

在这项工作中，放射性示踪剂 [ 99m Tc] 硝基-奥拉西坦复合物在 99m Tc-硝基作为核心的情况下被标记。为了获得最高的放射化学纯度，已经研究了许多有效因素，例如反应温度、反应时间、反应混合物的pH值、底物量和稳定性以得到高于99%的高百分比。最后，生物分布研究表明 [ 99m Tc] 硝基-奥拉西坦作为一种可用于脑成像的新型放射性示踪剂的便利性。注射后30分钟最大吸收量为10.6％。